Volume 28, Issue 170 (3-2019)
J Mazandaran Univ Med Sci 2019, 28(170): 180-185 |
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Mandegari A, Gholami-Javadie A, Jafari M, Sabouri S. Synergistic Therapeutic Effects of Cimetidine/Famotidine in Combination with Doxorubicin on Cancer Cell Lines. J Mazandaran Univ Med Sci 2019; 28 (170) :180-185
URL: http://jmums.mazums.ac.ir/article-1-11583-en.html
URL: http://jmums.mazums.ac.ir/article-1-11583-en.html
Abstract: (4328 Views)
Background and purpose: Combination therapy in cancer is a promising approach to increase efficacy and tolerability and to decrease adverse effects and drug resistance. Recently, anti-cancer properties of H2-receptor antagonists have been reported in several pre-clinical and clinical studies. The aim of this study was to examine the effect of cimetidine and famotidine H2-blockers on cytotoxicity of doxorubicin (DOX) on A549, MCF-7, and HT-29 human cancer cell lines.
Materials and methods: The cytotoxicity of cimetidine and famotidine, alone and in combination with DOX, was determined using MTT assay after 24 h incubation.
Results: Co-administration of H2-blockers with DOX led to an increase in cytotoxicity of the cell lines studied. While DOX at 1 μM could not reduce the viability of the cultured cells below 50%, its use in combination with cimetidine or famotidine at 25 μM reduced the percentage of viable cells below 50%.
Conclusion: Combination of cimetidine/famotidine with DOX could be a potential candidate for chemotherapy.
Materials and methods: The cytotoxicity of cimetidine and famotidine, alone and in combination with DOX, was determined using MTT assay after 24 h incubation.
Results: Co-administration of H2-blockers with DOX led to an increase in cytotoxicity of the cell lines studied. While DOX at 1 μM could not reduce the viability of the cultured cells below 50%, its use in combination with cimetidine or famotidine at 25 μM reduced the percentage of viable cells below 50%.
Conclusion: Combination of cimetidine/famotidine with DOX could be a potential candidate for chemotherapy.
Type of Study: Brief Report |
Subject:
toxicology
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