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Background and purpose: Vitamin C and CoQ10 are known as two potentantioxidants. We studied the protective Role of CoQ10 and ascorbic acid against Ischemia-Reperfusion. Finally, we have compared the therapeutic effect of these two together. Materials and methods: 35 male balb-Cwere divided into seven subgroups. Includes five groups: intact, ischemicControl, sham Control and treatment groups with CoQ10 and treatment groups with ascorbic acid. In treatment groups, the mice treated with CoQ10 and vitC as Pre-Treatment for a week. Then, ischemia induced by Common Carotid artery ligation. The mice post-treated with CoQ10and ascorbic acidfor a week. Nissl staining applied to counting necroticCells of hippocampus. TUNNEL kit was used to quantify apoptoticCell death while to short term memory scale, we apply y-maze and shuttle box tests. Results: High rate of apoptosis was seen in ischemic group associated with significantly short-term memory loss. In the treatment groups withthese antioxidants, Cell death was significantly lower than the ischemic Control group. Between treatment groups, group treated with CoQ10 was less neuronal death than the group treated with ascorbic acid. Conclusion: According to the results of this study, ascorbic acid and CoQ10 intake significantly reduced Cell death and decreased memory loss. Butthe antioxidant effect of CoQ10 is stronger than vitamin C in this zone of brain.

Keywords: Hippocampus, Ischemia-Reperfusion, neuroprotective effect, CoQ10, ascorbic acid

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