Background and purpose: Nanotechnology researchers have identified a wide range of nanoparticle uses that may have an important role in medicine, prevention and treatment of diseases. Paucity of information on toxicity of silver nanoparticles made the authors to evaluate the effect of silver nanoparticles on the enzyme creatine phosphate kinase. Materials and methods: In this study, 40 adult male Wistar rats with average weight of 220 ± 20 gr were injected with 50, 100, 200, and 400 PPm of nanosilver particle in five consecutive days. Then three, eight and twelve days after the last injection, blood sampling was performed and skeletal tissue samples from the muscle were stained using hematoxylin-eosin. To investigate the effect of nanosilver on Phospho creatin kinase ANOVA was used in different days. Results: Different concentrations of silver nanoparticles has no significant effect on the phospho creatin kinase activity (p=0.841), but the effect of time was apparent on this activity (p=0.005). In fact the mean of the phospho creatin kinase activity increased in all concentrations of nanosilver after eight days. Histological changes were also occurred in 400 PPm doses of silver nanoparticles. Conclusion: Development of nanotechnology has increased its use in cosmetic and medical supplies. So precautions are needed when using appliances containing silvre nanoparticle.

Keywords: Silver nanoparticle‚ phospho creatin kinase‚ muscle tissue

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