Volume 33, Issue 2 (12-2023)                   J Mazandaran Univ Med Sci 2023, 33(2): 61-70 | Back to browse issues page

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Abstract:   (405 Views)
Background and purpose: Colonoscopy is a standard method for the diagnosis and treatment of colorectal diseases. The aim of the present study was to compare the analgesic effect of oral oxycodone and intravenous fentanyl in patients undergoing colonoscopy.
Materials and methods: This study was conducted as a randomized clinical trial in 80 patients aged 20 to 69 years who were candidates for colonoscopy in two equal groups. Patients in the first group received oral oxycodone and intravenous normal saline, while the second group received oral placebo and 50 micrograms of intravenous fentanyl. 0.5 mg/kg propofol was administered intravenously to both groups. If pain occured, 10 mg propofol was injected. Data on age, gender, vital signs, satisfaction of the endoscopist and pain intensity of the patients were recorded using a numerical rating scale. The data were analyzed using the chi -square test and t-test and SPSS software, with a P˂0.05 value considered significant.
Results: The two groups were similar in terms of age (P=0.64) and gender (P=0.055).The mean pain score in the oxycodone group was 3.22±1.78 and in the fentanyl group 2.00±1.43 (P= 0.001). The need for a propofol rescue dose during colonoscopy was higher in the oxycodone group than in the fentanyl group (P= 0.56). There were no significant differences between the two groups in terms of heart rate, respiratory rateand colonoscopist satisfaction (P>0.05).
Conclusion: Considering that oral oxycodone has a good analgesic effect compared to intravenous fentanyl, this drug can be used as an analgesic for patients undergoing colonoscopy.

(Clinical Trials Registry Number: IRCT20181216041991N1)
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Type of Study: Research(Original) | Subject: anesthesia

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