Expression of Bcl-2 Gene in Primary Breast Cancer and its Correlation with Some Prognostic Factors - Journal of Mazandaran University of Medical Sciences
Volume 17, Number 58 (May 2007)                   J Mazandaran Univ Med Sci 2007, 17(58): 30-36 | Back to browse issues page


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Jalali Nadoushan M, Davati A, Tavakoli A. Expression of Bcl-2 Gene in Primary Breast Cancer and its Correlation with Some Prognostic Factors. J Mazandaran Univ Med Sci. 2007; 17 (58) :30-36
URL: http://jmums.mazums.ac.ir/article-1-210-en.html

Abstract:   (8336 Views)
Background and purpose: The breast cancer is the most common malignancy in women. Bcl-2 expression has been determined in more than half of the cases of breast cancer. The purpose of this study was to determine the expression of bcl-2 gene in primary breast cancer and its correlation with grade, stage and axillary lymph node involvement.
Materials and Methods: The study was a cross-sectional one that was performed on 75 patients with breast cancer admitted to Mostafa Khomeini hospital (2000-2005). After preparing the samples, a tissue section from each sample was obtained. One of the tumoral sections and one of the lymph node sections were stained using H & E. We determined the type of the tumor, the number of lymph nodes, the stage and the grade of the tumor. We studied Bcl-2 with polyclonal antibody by IHC.
Results: Our study showed that 69.3% of patients had hymph node involvment. In addition, 41.3% of samples were positive for Bcl-2, 58.7% of samples were in stage II and many patients (42.7%) were in grade III. In this study, we didn’t find any relationship between bcl-2 and stage and lymph node involvment. We also found a significant association between bcl-2 and grade (P<0.006). Also, high bcl-2 expression was more frequent in high-grade tumor.
Conclusion: According to the results obtained from earlier studies and our study, it seems that bcl2 is a prognostic factor in breast cancer. But further investigations with more specimens and long-time follow-up are required to clarify the exact role of Bcl-2 in the prognosis of breast cancer.
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Type of Study: Research(Original) |

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