The Effect of Gonadectomy and Sex – Related Differences in Response to Matricaria Chamomilla Extract on Locomotor Activity Behavior in Mice - Journal of Mazandaran University of Medical Sciences
Volume 17, Number 58 (May 2007)                   J Mazandaran Univ Med Sci 2007, 17(58): 43-56 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Raei H, Kesmati M, Zadkarami M. The Effect of Gonadectomy and Sex – Related Differences in Response to Matricaria Chamomilla Extract on Locomotor Activity Behavior in Mice. J Mazandaran Univ Med Sci. 2007; 17 (58) :43-56
URL: http://jmums.mazums.ac.ir/article-1-212-en.html

Abstract:   (12333 Views)
Background and purpose: Former studies showed that the Matricaria chamomilla hedroalcholic extract affects pain and anxiety of male and female mice sex-dependently. In this research we examined the effect of Matricaria chamomilla (chamomile) hydroalcholic extract on locomotor activity behavior in presence and absence of sex glands in adult male and female NMRI mice.
Materials and Methods: Animals were divided into groups of seven including intact, sham, gonadectomized and receiving hydroalcholic extract of chamomile (30 and 50 mg/kg i.p). Motor activity monitor system was used to evaluate locomotor activity parameters (number of line crossing movments, stereotype movments and number of rearing movments) in open field test on all groups.
Results: 1) Hydroalcholic extract of chamomile (50 mg/kg dos) decreased motor activity parameters in presence and absence of sex glands in male mice. 2) Hydroalcholic extract of chamomile (50 mg/kg dose) increased motor activity parameters in presence and absence of sex glands in female mice.3) Gonadectomy did not have any effect on locomotor activity parameters on male mice.4) Gonadectomy decreased motor activity parameters on female mice.
Conclusion: It seems that chamomile extract influences motor activity parameters via some sex related factors like neurochemical systems in male and female mice. This effect may in part depend on sex hormones receptors in female mice.
Full-Text [PDF 398 kb]   (1571 Downloads)    
Type of Study: Research(Original) |

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb