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Abstract Background and purpose: Ruta Graveolens (RG) commonly called sudab, has been known as a medicinal plant since ancient times. Anti-oxidant, anti-inflammatory, anti-tumor, anti-androgenic, and anti-fertility activities are amongst the medicinal properties of RG. The present study investigated the antifertility effects of RG and in-vitro embryo development in female mice. Materials and methods: The study was performed in 30 female mice that were divided into two groups as control and RG. The control group received normal saline 0.2 ml and the RG group received 300 mg/kg aqueous extract of RG per day, orally for 14 days. Matured oocytes were transported to HTF+BSA (4mg/ml). Then fertilized oocytes, two cell, blastocyst and hatching embryos were evaluated. Results: In case group RG reduced embryo growth (P<0.05) at different stages. However, by disrupting RG administration no significant differences were observed between control and test animals. Conclusion: The results showed that the aqueous extract of RG decreased the embryo growth and fertilizing ability in female mice. Moreover, the negative impact of RG on fertilizing potential is recurrentable after disruption of exposure.

Keywords: Anti-fertility, Rutagraveolens, Mice

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