Abstract Background and purpose: Ischemia-reperfusion (I/R) is present at various degrees in kidney transplants. Several studies suggest that renal ischemia reperfusion (RIR) can induce acute kidney injury. Olive leaf is a significant source of bioactive phenolic compounds. They have better antioxidant capacity, anti-inflammatory and radical scavenging. Materials and methods: In this study 50 male rats were randomly allocated into 5 groups: control group which were intact animals group-1(receiving I/R 60min+olive leaf extract), group-2(I/R 60min), group-3(I/R 120min+olive leaf extract) and group-4(I/R 120min).The animals received 100 mg/kg olive leaf extract in 0.5 ml drinking water using gavages for 28 days. At the end of the treatment, levels of antioxidant enzymes including SOD, GPX, TAC, and MDA, urea and creatinine level were determined in serum. Results: Results showed that urea and creatinine level in serum of treated groups was significantly lower than those of the ischemia-reperfusion groups (P=0.00). Also, MDA level in groups-2 and 4 was significantly higher than that of the control group (P=0.00). In addition, activity level of SOD and GPX enzymes in treated groups with olive leaf extract was significantly higher compared to those of the I/R groups (P=0.00). Conclusion: This study showed protective effect of olive leaf extract against renal ischemic-reperfusion injury.

Keywords: Ischemic injury, kidney reperfusion, antioxidant enzyme, male rat

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