Background and purpose: Depression is one of the most common psychiatric disorder that results in significant consequences in active population of the society. Ïn traditional manscripts there are many indications about the antidepressant effects of rose drops, but, sofar no scientific research has been done about this subject. The objective of present study is to determine the anti depressant effects of this plant.
Materials and Methods: This study was done on laboratory rats. Üsing the forced mandatory swimming test and the effect of Rosa in different concentrations was compared to the effects of placebo and amphetamine.
Results: Rose drops with a concentration of 5% had no antidepressant effect, but concentrations of 10% , 20% and 40% , reduced the depression significantly in Çomparision to placebo, which was similar to amphetamine.
Çonclusion: Since the anti depressant effect of Rose drops appeared acutely and in a short period of time, like amphetamine, it is probable that, it’s effect is due to release of pre-synaptic amines.

Keywords: Depression, Rosa Damascena, Âmphetamine

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