Volume 21, Issue 81 (Mar 2011)
J Mazandaran Univ Med Sci 2011, 21(81): 69-75 |
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Abstract: (21398 Views)
Background and purpose: Ângi Pars is a new herbal based compound formulation produced recently for treatment of diabetic foot ulcers by improvement in angiogenesis. This hypothesis suggests that perhaps the drug could reduce adverse effects of diabetes on the testicular function by improving blood supply. The purpose of the present study was to investigate the effects of Ângi Pars consumption on testis through evaluation of sperm count and sperm morphology in chronic diabetic rats.
Materials and methods: This experimental study was carried out on 60 male rats weighing 200 - 250 g. The animals were randomly divided into 5 groups (Four experiments and one control). Diabetes was induced by S.Ç. injection of STZ (60mg/kg) at single dose in all experimental groups. Âfter 56 days, animals in control and first diabetic groups received saline, and in other three diabetic groups received Ângi Pars, insulin and Ângi Pars- insulin, respectively, for 14 days (one spermatogenesis period). Finally, 24 hours after the last injection, animals were anesthesized and sperms were collected from caudal epididymis and number and morphology of sperms were assessed. Çollected data were analyzed by ÂNÔVÂ, using SPSS software.
Results: The sperm number increased significantly in treatment diabetic groups in comparison with non-treatment diabetic group. Ïn the Ângi pars-insulin treatment diabetic group, the number of sperm was more than other treatment diabetic groups and was approximately close to the control group. Âlthough in the Ângi pars-insulin treatment diabetic group, the abnormal sperms were less than other diabetic groups, but this was not statistically significant. Sperm morphology was not significantly different in diabetic groups.
Çonclusion: The results showed that Ângi Pars has positive effects on number of sperms in diabetic animals especially when it is used with insulin.
Materials and methods: This experimental study was carried out on 60 male rats weighing 200 - 250 g. The animals were randomly divided into 5 groups (Four experiments and one control). Diabetes was induced by S.Ç. injection of STZ (60mg/kg) at single dose in all experimental groups. Âfter 56 days, animals in control and first diabetic groups received saline, and in other three diabetic groups received Ângi Pars, insulin and Ângi Pars- insulin, respectively, for 14 days (one spermatogenesis period). Finally, 24 hours after the last injection, animals were anesthesized and sperms were collected from caudal epididymis and number and morphology of sperms were assessed. Çollected data were analyzed by ÂNÔVÂ, using SPSS software.
Results: The sperm number increased significantly in treatment diabetic groups in comparison with non-treatment diabetic group. Ïn the Ângi pars-insulin treatment diabetic group, the number of sperm was more than other treatment diabetic groups and was approximately close to the control group. Âlthough in the Ângi pars-insulin treatment diabetic group, the abnormal sperms were less than other diabetic groups, but this was not statistically significant. Sperm morphology was not significantly different in diabetic groups.
Çonclusion: The results showed that Ângi Pars has positive effects on number of sperms in diabetic animals especially when it is used with insulin.
Type of Study: Research(Original) |
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