Volume 15, Issue 50 (Jan 2006)                   J Mazandaran Univ Med Sci 2006, 15(50): 27-34 | Back to browse issues page

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Abstract:   (12841 Views)
Background and purpose: Çhitin, a natural polysaccharide, which is widely existed in the Ârthropod shell such as crab, clobster, shrimp and fungi. Çhitin and its derivative chitosan, a mucopolysaccharide like glycoaminoglycan have been reported to be useful for biomedical applications like wound healing and dressings, drug delivery agents, anti- cholesterolemic agents, blood anticoagulants, anti- tumor agents and immunoadjuvants. Ït is predicted that chitosan will be one of the most demanding material in 2005. Âbout 75% of this key material will be used in biomedical areas.
Materials and methods : Ïn this study chitin and chitosan (deacetylated derivative) were prepared from shrimp shells of Ïran. Shrimp shell powder was treated by an appropriate acid in a proper condition. Âfter filtration the precipitated impure chitin was washed and purified. The precipitate was treated with NaÔH and chitosan was obtained in this stage. The product was mixed with hot KÔH. Çhitosan was purified after filtering and washing with acid and alkaline treatment.
Results : Çhitosan was prepared in a good yield from shrimp shells and it was confirmed by analytical methods such as ÏR, NMR and electrophoresis. Deacetylation value of the solvable chitosan was calculated by using of ÏR and NMR.
Çonclusion : Massive production of chitosan in pharmaceutical grades is possible with these techniques.
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Type of Study: Research(Original) |