This case report describes the healing of a large periapical lesion without apical surgery.  In this paper, s 35 year-old female with a large lesion from the apices of her teeth 22-27 is presented. During treatment procedure 2.5% sodium hypoclorite solution was used for irrigation and calcium–hydroxide was used as intracanal anti-microbial dressing. Periapical healing was observed in radiographic examinations at 6-month and 1 and 2 year-follow-up visits.