Volume 26, Number 140 (9-2016)                   J Mazandaran Univ Med Sci 2016, 26(140): 192-196 | Back to browse issues page


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Asgari Hasanluyi E, Banan Khojasteh M, Fazeli M, Hatami H. Investigating the Neurotoxicity of Bisphenol A on Spatial Learning and Memory in Male Rats. J Mazandaran Univ Med Sci. 2016; 26 (140) :192-196
URL: http://jmums.mazums.ac.ir/article-1-8387-en.html

Abstract:   (1702 Views)

Background and purpose: Bisphenol A is a synthetic xenoestrogen that is used in large amount to produce polymers (polycarbonates, epoxy resins). It easily cross the blood-brain barrier and is reported to influence the central nervous system especially neurogenesis and synaptic transmission. In this research the effects of chronic administration of bisphenol A on spatial learning and memory in adult male rats was studied.

Materials and methods: Forty male Wistar rats were randomly divided into four groups (n= 10); a control and three BPA (10 and 50 and 100 µg/kg) groups. Bisphenol A was administered intraperitoneally for 15 days. The morris water maze was used to study the spatial learning and memory for 5 consecutive days. Data analysis was performed using one-way ANOVA.

Results: Compared with the control group, treatment with BPA in 10 and 50 µg/kg doses reduced spatial memory (P<0.05). Reduction of spatial memory in the group treated with 100 μg/kg BPA was very severe compared with the control group (P<0.01).

Conclusion: Results showed that bisphenol A increased the distance and latency time in finding the hidden platform. It seems that bisphenol A has negative effects on spatial memory by affecting synaptic transmission in central nervous system.

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Type of Study: Brief Report | Subject: physiology

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