Phonophoresis is a method for topical medications to better penetrate the skin via ultrasound. Its actual mechanism has not been well defined, but it could be due to increased cell permeability from the thermal effects of ultrasound. Some indications for phonophoresis include: osteoarthritis, bursitis, neuromas, adhesions, scar tissues. Here we present a 55 year old woman who was a known case of Grave’s disease presenting with pretibial myxedema. The edema did not respond to common treatments but improved following the use of phonophoresis with clobetasol significantly improved.

Keywords: Myxedema, Grave’s disease, phonophoresis, clobetasol

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