TY - JOUR T1 - Effect of metformin on the levels of leptin and insulin TT - تاثیر مت فورمین بر سطح خونی هورمون لپتین و انسولین JF - J-Mazand-Univ-Med-Sci JO - J-Mazand-Univ-Med-Sci VL - 16 IS - 52 UR - http://jmums.mazums.ac.ir/article-1-122-en.html Y1 - 2006 SP - 33 EP - 39 KW - Leptin KW - metformin KW - insulin KW - obesity N2 - Background and purpose : Leptin and insulin are secreted from fat and Pancrease tissues respectively. They decrease food consumption and regulate homeostasis of body weight via central nervous system. Metformin is an anti hyperglycemia which is used for treatment of type 2 diabetes. The aim of this study was investigating correlation between leptin and insulin levels before and after treatemnt with metformin in type ÏÏ diabetic patients. Materials and methods : Ïn this clinical trail, 25 cases type ÏÏ diabetic patients with BMÏ greater than 30 Kg/m2, (mean age 52 ± 12 years) were selected. They received treatment with metformin (1000 mg twice daily) for one month, then a fasting blood sample was taken and analyzed. Results : Results showed a significant changes in mean of glucose (P M3 ER -