RT - Journal Article T1 - Effect of Muscimol on hyperglycemia, caused by I.C.V. injection of GABA.A receptor antagonists Bicuculline and picrotoxin and its role on regulation of blood glucose in mice. JF - J-Mazand-Univ-Med-Sci YR - 2000 JO - J-Mazand-Univ-Med-Sci VO - 10 IS - 28 UR - http://jmums.mazums.ac.ir/article-1-304-en.html SP - 1 EP - 8 K1 - Hyperglycemia K1 - GÂBÂ-Â receptor K1 - Blood glucose homeostasis K1 - Mice AB - Background and purpose: The regulation of blood glucose is one of the complex phenomenon which is affected by several hormonal and neural systems. Beside hormonal factors, neurological factors, such as different neurotransmitters, including Gama amino buturic acid (GÂBÂ) present in nervous system of mammals playa role in regulation of blood glucose level. Materials and Methods: Ïn this study male albino rats with weight rang of 20-25 gms were selected and intracerebroventricular (Ï.Ç.V.) injection of GÂBÂ-Â receptor antagonists (picrotoxin 50ng and bicuculline 25ng) and GÂBÂ-Â receptor agonist (muscimol 25 and 50 ng) was given to experimental group animals and results were compared with control group which received only normal salin. The mean value of blood glucose variation in each dose was determined and statistical analysis was done by one way variation and also student’s T.test. Âny how the point of significancy was considered as (P LA eng UL http://jmums.mazums.ac.ir/article-1-304-en.html M3 ER -