RT - Journal Article T1 - Incidence of chemotherapy-induced amenorrhea in non-menopausal women with breast cancer JF - J-Mazand-Univ-Med-Sci YR - 2009 JO - J-Mazand-Univ-Med-Sci VO - 19 IS - 70 UR - http://jmums.mazums.ac.ir/article-1-544-en.html SP - 9 EP - 17 K1 - Breast cancer K1 - amenorrhea K1 - chemotherapy K1 - on K1 - menopausal women AB - Background and purpose: Although adjunct chemotherapy may increase life in non-menopausal breast cancer patients، however، it may cause short-term complications such as nausea، vomiting، alopecia، as well as long-term complications in ovarian failure and premature menopausal. The objective of this study was to investigate chemotherapy-induced secondary amenorrhea in non-menopausal women with breast cancer. Materials and methods: A descriptive design (case series) was preformed on fifty breast cancer patients، non-menopausal (normal mense) and chemotherapy in Ramsar Emam Sajad Hospital Oncology unit from 2007 to 2008. Sampling was consecutive. Data gathering method was questionnaire & blood sampling (FSH & Progesterone) for prior and 12 months after the end of chemotherapy. Data was analyzed by paired-t، independent-t and one-way ANOVA tests. Results: Results showed that 62% of patients were amenorrhea 12 months after the end of chemotherapy. Results showed that there was no meaningful relationship between age، hormone therapy، disease stage، node-positive and ER & PR status to amenorrhea however، there was a meaningful relationship between duration of treatment، type and dose of chemotherapy to amenorrhea. Conclusion: In pre-menopausal patients with breast cancer، receiving cytotoxic chemotherapy against tumor cells، amenorrhea may occur do to ovarian failure. LA eng UL http://jmums.mazums.ac.ir/article-1-544-en.html M3 ER -