TY - JOUR T1 - Evaluation of serum level of IL-12 in patients withoccult HBV infection TT - بررسی سطح سرمی اینترلوکین 12 در بیماران مبتلا به عفونت نهفته هپاتیت B (گزارش کوتاه) JF - J-Mazand-Univ-Med-Sci JO - J-Mazand-Univ-Med-Sci VL - 19 IS - 73 UR - http://jmums.mazums.ac.ir/article-1-592-en.html Y1 - 2009 SP - 80 EP - 83 KW - Occult hepatitis B infection KW - IL-12 KW - HBsAg KW - HBV-DNA N2 - Background and purpose:Occult hepatitis B infection (OBI) is a form of hepatitis in which despite the absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. Investigators believed that the genetics and immunological parameters may be different in resistant individuals and patients. Cytokines, such as IL-12, could be leading to alteration in viral immune response. The main aim of this study was to investigate the serum level of IL12 in OBI patients. Materials and methods:In this study, the plasma samples of 3700 HBsAg negative blood donors were tested for anti-HBs by ELISA. The HBsAg negative and anti-HBc positive samples were selected and screened for HBV-DNA by PCR. HBV-DNA positive samples were assigned as OBI cases and ELISA technique were performed to examine the serum level of IL-12 in OBI and 100 healthy controls. Results:Our results showed that there was no significant difference in serum level of IL-12 between OBI patients and controls. Conclusion:In order to be clear of viruses, L-12 is increased in viral infection. Based on the results of this study, it is concluded that OBI patients can not produce enough IL-12 to clear HBV. M3 ER -