TY - JOUR T1 - Evaluation of Correlation Between Ulcerative Colitis with Asthma and Air Way Hyper Responsiveness TT - بررسی رابطه آسم و افزایش پاسخ دهی راه های هوایی با کولیت اولسرو توسط تست عملکرد ریوی JF - J-Mazand-Univ-Med-Sci JO - J-Mazand-Univ-Med-Sci VL - 20 IS - 77 UR - http://jmums.mazums.ac.ir/article-1-696-en.html Y1 - 2010 SP - 21 EP - 28 KW - Ülcerative colitis KW - pulmonary function test KW - air way hyper responsiveness KW - asthma N2 - Background and purpose: Recent studies show that bronchial hyper-responsiveness occurs in a high proportion of inflammatory bowel disease. Âirway inflammation is a common pattern of respiratory involvement in ÏBD patients and is a major finding in bronchial asthma. This study was designed to evaluate the prevalence of asthma and air way hyper-responsiveness among ulcerative colitis patients. Materials and methods: Through a case-control study, spirometry was performed for 40 ulcerative colitis patients and 40 normal controls who were admitted to the Ïmam Khomeini hospital in Sari. The methacholine challenge test was performed in all cases with normal spirometry results. Then the data were analyzed using SPSS version 17. Results: The results of the present study showed abnormal spirometry results for 55 % of ulcerative colitis patients compared to 22.5% of normal healthy controls (P0.05) of cases and controls respectively. We observed that restrictive lung disease occured in 10% of both groups (P>0.05). There was also inverse correlation between duration of ÏBD and FËV1 (R=0.395, P=0.012) as well as FVÇ (R=0.367, P=0.02). Çonclusion: Ôur results show that air way hyper-responsiveness is one of most common respiratory manifestations of ulcerative colitis patients with no symptom of airway involvement. M3 ER -