TY - JOUR JF - J-Mazand-Univ-Med-Sci JO - J Mazandaran Univ Med Sci VL - 22 IS - 95 PY - 2012 Y1 - 2012/11/01 TI - Effects of Alcoholic Extract of Peganumharmala L. on Malondialdehyde Concentration and Catalaseand Glutathione Peroxidase Activity in Mice Treated with Nanosilver Particles TT - تأثیر عصارهالکلی اسپند بر غلظت مالون دی آلدئید و فعالیت کاتالاز و گلوتاتیون پر اکسیداز در موش های تیمار شده با نانو ذرات نقره N2 - Background and purpose: Nanosilver particles are associated with oxidative stress due to free radical production. Long-term use of antioxidant agents could result in harmful production of free radicals. This study assessed the protective and antioxidant effects of Peganumharmala L.onmalemicetreated with nanosilver particles. Materials and methods: In this study 32 male Albino mice (25-30gr) were divided into four groups one control group and three intervention groups. The intervention groups included a group receiving 500 ppm nanosilver particles, a group fed 20 mg/kg/day by ethanolic extract of P.harmalafor 30 days, and a group which was given ethanolic extract of P.harmalaorally and the same dose of nanosilver particles. Onthreeconsecutive day sat the beginning of the experiment intraperitoneal injections of nanosilver were performed. Post-treatment blood samples were collectedfromthe hearts and the activity of serum catalase (CAT) and glutathioneperoxidase (GPx) I nredblood cell and concentration of serummalondialdehyde (MDA) were determined. Results: In the mice treated with nanosilver particles the MDA concentration significantly increased, while significant decreases were seen in GPx and CAT activities (P SP - 10 EP - 17 AU - Karam Sichani2, Samir AU - Naghsh, Nooshin AU - Razm, Nematallah AD - KW - Nanosilver KW - Peganumharmala KW - catalase KW - glutathioneperoxidase KW - malondialdehyde UR - http://jmums.mazums.ac.ir/article-1-1509-en.html ER -