TY - JOUR T1 - Reporting Three Cases of Roger’s Syndrome in Children TT - گزارش سه مورد از سندرم روجر در کودکان JF - J-Mazand-Univ-Med-Sci JO - J-Mazand-Univ-Med-Sci VL - 22 IS - 89 UR - http://jmums.mazums.ac.ir/article-1-1512-en.html Y1 - 2012 SP - 122 EP - 127 KW - Megaloblastic anemia KW - diabetes mellitus KW - sensory neural hearing loss KW - roger syndrome N2 - Roger’s syndrome is a rare form of diabetes in children that is characterized with early onset of diabetes mellitus, megaloblastic anemia, and sensory neural hearing loss. In this report three cases of this syndrome from consanguineous Iranian families are introduced (two siblings and a cousin). They referred to pediatric ward of Imam Reza Hospital with hyperglycemia, anemia and sensory neural hearing loss. Molecular genetics study revealed novel mutation in SLC19A2 gene. Thiamin was used in order to treat the patients. Afterwards, anemia was resolved in all patients and normoglycemia achieved in two of the patients, however, hearing loss remained in all three. M3 ER -