TY - JOUR T1 - Efficacy of a Triple-Drug Combination (Hydroquinone 5%, Salicylic Acid 4% and Fluocinolone 0.1%) in Treatment of Melasma TT - بررسی اثرات درمانی ترکیب سه دارویی (هیدروکینون موضعی 5 درصد، سالیسیلیک اسید 4 درصد، فلوسینولون 01/0 درصد) در بیماران مبتلا به ملاسما JF - J-Mazand-Univ-Med-Sci JO - J-Mazand-Univ-Med-Sci VL - 24 IS - 122 UR - http://jmums.mazums.ac.ir/article-1-5318-en.html Y1 - 2015 SP - 361 EP - 366 KW - Melasma KW - treatment KW - hydroquinone KW - fluocinolone KW - salicylic acid N2 - Background and purpose: Melasma is a pigmentation of facial area that is seen mostly in women. Endocrine disorders are involved in development of melasma. This study was designed to evaluate the topical effect of a triple combination therapy in patients with melasma. Materials and methods: This clinical trial was conducted in 70 patients with melasma attending a Dermatology Clinic. All patients with melasma received triple combination (hydroquinone 5%, salicylic acid 4%, and fluocinolone 0.01%) and vitamin C 2% for 6 months. The efficacy of treatment was evaluated based on Melasma Area and Severity Index (MASI) Score and patients’ satisfaction was evaluated according to a questionnaire based on Satisfaction Index (SI). Data analysis was performed applying qui square test, binomial test, and repeated measures ANOVA. Results: Among the patients 93% were women and the mean age of participants was 35.21±7.5. Mean MASI Score was 27.07±10.24 at the beginning of the treatment and a significant decrease was seen at the end of first month (7.17±3.64), second (6.97±2.97), third (8.64±3.77), fourth (8.96±4.77), and sixth months (7.77±4.86). Conclusion: Triple combination therapy (hydroquinone 5%, salicylic acid 4%, and fluocinolone 0.01%) was found effective in treatment of melasma and could be used as a new protocol. M3 ER -