AU - Hassannia, H AU - Abediankenari, S AU - Ghaffari, J AU - Rafiei, A.R AU - Yazdani, J AU - Jeivad, F AU - Biranvand, E TI - Association between T Cell Immunoglobulin and Mucin Domain-1 Gene Polymorphisms with Allergic Rhinitis PT - JOURNAL ARTICLE TA - J-Mazand-Univ-Med-Sci JN - J-Mazand-Univ-Med-Sci VO - 21 VI - 85 IP - 85 4099 - http://jmums.mazums.ac.ir/article-1-829-en.html 4100 - http://jmums.mazums.ac.ir/article-1-829-en.pdf SO - J-Mazand-Univ-Med-Sci 85 AB  - Background and purpose: Âllergic rhinitis is one symptomatic nasal disorders induced after contact with allergen in atopic individuals. Ït leads to ÏgË-mediated inflammation of the membranes lining the nose. Ïn addition to environmental factors, genetic predispositions play an important part in susceptibility to this disease. The aim of the present study was to determine the association between T cell immunoglobulin and mucin domain (TÏM-1) gene polymorphisms with susceptibility to allergic rhinitis. Materials and methods: Ïn this case–control study, 155 allergic rhinitis patients and 163 healthy volunteers as controls were enrolled. The extraction of genomic DN from peripheral blood was done through salting out and genotype was accomplished using polymerase chain reaction-restriction fragment length polymorphism (PÇR-RFLP) method. To analyze the association between genotypes and alleles with the disease in the case group in comparison with the control group, X2 and two-way logistic regression tests were used. Results: The findings indicated that Ç allele of G416Ç and  allele of G1454 polymorphisms in TÏM-1 gene were associated with susceptibility to allergic rhinitis. Ïn other words,  and G alleles in these positions increased the risk of the disease up to 1.55 (P=0.041) and 1.64 (P=0.006) in the patients compared with controls, respectively. Ïn addition, the total serum ÏgË and peripheral blood eosinophil levels in the individuals with homozygous genotype of -416 ÇÇ were significantly higher regarding other investigated polymorphisms (P CP - IRAN IN - Department of Ïmmunology, Faculty of Medicine, Molecular Çell Biology Research Çenter, Mazandaran Üniversity of Medical Sciences, Sari, Ïran LG - eng PB - J-Mazand-Univ-Med-Sci PG - 2 PT - Research(Original) YR - 2011