TY - JOUR JF - J-Mazand-Univ-Med-Sci JO - J Mazandaran Univ Med Sci VL - 28 IS - 160 PY - 2018 Y1 - 2018/5/01 TI - Effect of Andrographolide on Paraoxonase 2 Expression in Male Wistar Rats TT - بررسی تاثیر آندروگرافولید روی بیان آنزیم پاراکسوناز 2در موش‌ صحرایی نر نژاد ویستار N2 - Background and purpose: The paraoxonase 2 is one of the paraoxonase family enzymes, which, unlike the paraoxonase 1 and 3, is an intracellular antioxidant system expressed in many cells. Andrographophyllide is a plant that has recently received attention and is used in many fields due to different properties, including antioxidant property. The purpose of this study was to evaluate the effect of andrographolide on paraoxonase 2 expression. Materials and methods: In this study, 18 Wistar rats were divided into three groups, including a control group (receiving physiologic serum) and two experimental groups that received 3.5 mg/kg andrographolide and 7 mg/kg andrographolide. Real-time PCR was performed to evaluate the expression of paraoxonase 2. Results: Compared to the control group, andrographolide at 3.5 and 7 mg/kg body weight reduced the liver expression of paraoxonase 2. The rate of expression of paraoxonase 2 was somewhat similar in both doses. Conclusion: To the best of our knowledge, for the first time, current study showed that injection of andrographolide extract at 3.5 and 7mg/kg body weight of male rats reduced the expression of liver paraoxonase 2. SP - 1 EP - 7 AU - Alipanah Moghadam, Reza AU - Mehri, Arash AU - Naghizadeh Baghi, Abbas AU - Nemati, Ali AU - Malekzadeh, Vadoud AU - Mazani, Mohammad AU - Manafi, Farideh AU - Mohammadzadeh-Vardin, Mohammad AU - Mohammadnia, Alireza AD - Associate Professor, Department of Clinical Biochemistry, Faculty of Medicine, Ardabil University of Medical Sciences, Ardebil, Iran KW - Paraoxonase 2 KW - Wistar rat KW - andrographolide UR - http://jmums.mazums.ac.ir/article-1-10673-en.html ER -