TY - JOUR JF - J-Mazand-Univ-Med-Sci JO - J Mazandaran Univ Med Sci VL - 28 IS - 170 PY - 2019 Y1 - 2019/3/01 TI - Comparing the Effect of Dexmedetomidine and Remifentanil on Hemodynamic Indices in Children Undergoing Endotracheal Intubation: A Randomized Clinical Trial TT - مقایسه تاثیر تجویز داخل بینی دکسمدتومیدین و رمی فنتانیل بر شاخص های همودینامیک کودکان تحت لوله گذاری داخل تراشه: کارآزمایی بالینی تصادفی شده N2 - Background and purpose: Painful stimulation during laryngoscopy and endotracheal intubation results in increased hemodynamic side effects. The aim of current study was to compare the effects of intranasal dexmedetomidine and remifentanil on reduction of hemodynamic changes following endotracheal intubation in children undergoing general anesthesia. Materials and methods: A double-blind clinical trial was performed in 104 children aged 6-12 years old, undergoing general anesthesia in Isfahan Imam Hossein Hospital, Iran, 2017-2018. Patients were randomly assigned into three groups to receive intranasal (IN) remifentanil 4µg/kg, dexmedetomidine 2µg/kg (IN), or normal saline 1mL, 0.9% (IN) before the induction of anesthesia. Hemodynamic changes were recorded at one and five minutes following intubation. ANOVA and Chi-square were applied to analyze the data. Results: Heart rate was higher in patients receiving normal saline and lower in patients receiving dexmedetomidine (p=0.22). Mean arterial blood pressure (p=0.98) and arterial oxygenation (p=0.81) were not significantly different between the three groups. No significant side effects were observed in any group. Conclusion: Administration of pre-intubation intranasal dexmedetomidine, results in heart rate stabilization following intubation. (Clinical Trials Registry Number: IRCT20160301026866N7) SP - 74 EP - 83 AU - Shafa, Amir AU - Shetabi, Hamidreza AU - Askarian, Mahdieh AD - Assistant Professor, Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran KW - intubation KW - dexmedetomidine KW - remifentanil KW - intranasal KW - hemodynamics UR - http://jmums.mazums.ac.ir/article-1-12118-en.html ER -