en بررسی کلینیک و پاتولوژیک و عوامل مرتبط با ضایعات حنجره در بیماران بیوپسی شده در بیمارستان بوعلی ساری، یک مطالعه ده ساله 1398-1388 آسيب شناسي(پاتولوژی) Pathology پژوهشي-کامل Research(Original) <strong><span dir="RTL">&nbsp;</span></strong><span style="font-size:12pt"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">ابتلا به سرطان</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">های حنجره با مرگ و میر و نیزناتوانی بالایی همراه است. از آن</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">جایی</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">که هیچ تست غربالگری موثری برای این بیماری به اثبات نرسیده است، به نظر می</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">رسد بهترین راه جهت کنترل بیماری، شناخت و حذف فاکتورهای مستعدکننده از زندگی افراد است. لذا این مطالعه به قصد برداشتن گامی موثر در جهت شناخت ریسک فاکتورها و عوامل موثر بر نوع و پروگنوز ضایعات حنجره انجام شد.</span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">در این مطالعه مقطعی، اطلاعات کلیه بیمارانی که طی سال</span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">های 88 لغایت 98 در بیمارستان بوعلی شهر </span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">ساری بیوپسی شده بودند و پرونده داشتند، جمع</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">آوری گردید. در این بیماران تمام ضایعات حنجره اعم از خوش</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">خیم و بدخیم از منظر کلینیکوپاتولوژیک بررسی شد. بدین</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">صورت که از طریق پرونده خوانی، اطلاعات دموگرافیک و بالینی بیماران نظیر سن، جنسیت، تشخیص بالینی و پاتولوژیک، محل عود، موارد عود و نوع خوش</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">خیمی جمع</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">آوری و آنالیز شد.</span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">423 بیمار بررسی شدند. از میان این افراد 331 نفر(78/3 درصد) مرد و 92 نفر (21/7 درصد) زن بودند. 254 نفر</span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar=""> (60</span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">درصد) ساکن شهر و 169 نفر (40</span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">درصد) ساکن روستا، 189 نفر (44/6</span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">درصد) سابقه مصرف مواد مخدر، 136 نفر (32 درصد) سابقه مصرف الکل و 312 نفر (74 درصد) سابقه استعمال دخانیات داشتند. در مطالعه حاضر، درگروه دارای بدخیمی میانگین سنی بروز ضایعات در طی سال</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">های مورد بررسی </span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">کاهش داشته است ولی </span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar="">د</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">رضایعات خوش</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">خیم، میانگین سنی بروز ضایعات به</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">طور معنی</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">داری افزایش پیدا کرده است(0/05</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%">P<</span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar="">)</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">.</span></span> <span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">همچنین مردان در مقایسه با زنان ریسک ابتلای بیش</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">تری به ضایعات غیر بدخیم دارند.</span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:90%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">این مشاهدات بیانگر یک هشدار بوده و لازم است در برنامه</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span b="" style="font-family:" zar="">‌</span></span><span lang="FA" style="line-height:90%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">های آموزشی- اجتماعی و اپیدمیولوژیک جهت اقدامات پیشگیرانه در نظر گرفته شود.</span></span></span></span></span></span></span></span></span></span></span><br> &nbsp; <pre class="tw-data-text tw-text-large XcVN5d tw-ta" data-placeholder="Translation" dir="ltr" id="tw-target-text" style="text-align:left"> <span style="font-size:12pt"><span style="line-height:135%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:135%">Laryngeal cancers are associated with high rates of mortality and disability. No effective screening test is proven for this disease, so, the best way seems to be controlling the disease by identifying and eliminating individual predisposing factors. The aim of this study was to pave the way for a better understanding of the risk factors and factors affecting the type and prognosis of laryngeal lesions<b>.</b></span></span></span></span></span> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:135%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span arial="" style="font-family:">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:135%">A cross-sectional study was performed using the records of patients who had a biopsy in Sari Bu Ali Hospital, between 2009 and 2019. Demographic and clinical information such as age, gender, clinical diagnosis, pathological diagnosis, location of recurrence, recurrent cases, and type of benign tumors were collected.</span></span></span></span></span></span></span></span> <span style="font-size:12pt"><span style="line-height:135%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span arial="" style="font-family:">Results:</span></span></span></b><b> </b><span lang="EN" style="font-size:10.0pt"><span style="line-height:135%">We studied </span></span><span style="font-size:10.0pt"><span style="line-height:135%">423 patients, including 331 (78.3%) males and 92 (21.7%) females, 254 (60%) lived in cities and 169 (40%) patients lived in rural areas. History of narcotics consumption, alcohol, and smoking were seen in 189 (44.6%), 136 (32%), and 312 (74%). respectively. In patients&nbsp; with malignancies, the mean age at onset of disease decreased during the years of study, but in patients with benign lesions the average age of incidence of lesions has increased significantly (P<0.05). In this study, men were found to be at higher risk of developing non-malignant lesions than women.</span></span></span></span></span> <span style="font-size:12pt"><span style="line-height:135%"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:135%"><span arial="" style="font-family:">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:135%"> These findings are a warning and should be considered in educational social and epidemiological programs for preventive measures.<i></i></span></span></span></span></span></span> </pre> <pre class="tw-data-text tw-text-large XcVN5d tw-ta" data-placeholder="Translation" dir="ltr" style="text-align:left"> </pre> تومور حنجره, ارزیابی کلینیکوپاتولوژیک, بیوپسی laryngeal tumor, clinicopathological evaluation, biopsy 67 78 http://jmums.mazums.ac.ir/browse.php?a_code=A-10-13936-1&slc_lang=en&sid=1 Somayeh Sheidaei سمیه شیدایی s.sheidaie2015@yahoo.com 1003194753284600143104 1003194753284600143104 No Assistant Professor, Department of Pathology, Faculty of Medicine, Mazandaran University of. Medical Sciences, Sari, Iran استادیار، گروه پاتولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران Mahsa Salehi مهسا صالحی mahsa.salehi2020@gmail.com 1003194753284600143105 1003194753284600143105 Yes Pathology Resident, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran دستیار پاتولوژی، گروه پاتولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران Rostam Pourmousa رستم پورموسی rpoormousa@gmail.com 1003194753284600143106 1003194753284600143106 No Assistant Professor, Department of Otolaryngology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran استادیار، گروه گوش و حلق و بینی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران Maryam Ghasemi مریم قاسمی a.zghasemi@yahoo.com 1003194753284600143107 1003194753284600143107 No Professor, Department of Pathology, Immunogenetics Research Center, Mazandaran University of. Medical Sciences, Sari, Iran استاد، گروه پاتولوژی، مرکز تحقیقات ایمیونوژنتیکس، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران