Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
1
admin
1735-9260
1735-9279
fa
jalali
1401
6
1
gregorian
2022
9
1
32
212
online
1
fulltext
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مقایسه سطح پروکلسیتونین سرم در بیماران با تشدید حاد بیماری مزمن انسدادی ریه و بیماران با تشدید حاد آسم
Comparing Serum Procalcitonin Levels Between Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Patients with Acute Exacerbation of Asthma
داخلی
Internal medicine
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">پروکلسیتونین سرم (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">PCT</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">) نشانگر عفونت باکتریایی است که می</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">تواند تجویز آنتیبیوتیک را کاهش دهد. بنابراین مطالعه حاضر با هدف مقایسه پروکلسیتونین سرم در بیماران با تشدید حاد </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">COPD</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> و آسم و ارتباط آن با عملکرد ریه و فاکتورهای التهابی انجام پذیرفت.</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">در این مطالعه توصیفی- تحلیلی از نوع مقطعی، بیماران با تشدید حاد آسم (46 نفر) و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.1pt">COPD</span></span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt"> (23 نفر)</span></span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> <span style="letter-spacing:-.2pt">مراجعهکننده به بیمارستان کاشانی شهرکرد، در سال 1399، وارد مطالعه شدند و پس از کسب اطلاعات کلینیکی و دموگرافیک،</span> تحت اسپیرو</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">متری</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> قرار گرفته و پروکلسیتونین، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">ESR</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">، گلبول</span></span><span dir="LTR" lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">‎</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">های سفید و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">PMN</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> نمونه خون آنها تعیین شد. دادهها توسط نرمافزار </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">SPSS</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> نسخه 19</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> تجزیه و تحلیل شد.</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">بیماران با تشدید </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">COPD</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> و آسم بر حسب سن، جنس، بستری در </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">ICU</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> و درصد </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">FEV1</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> تفاوت معنی‎داری داشتند (0/05</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P<</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">) ولی بر حسب میانگین </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">ESR</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">WBC</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">PMN</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> تفاوت معنی‎داری نداشتند (0/05</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P></span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">).</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> نتایج </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">PCT</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> مثبت نیز در گروه</span></span><span dir="LTR" lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">های آسم و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">COPD</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> به ‎ترتیب 8/7 و 56/5 درصد بود که تفاوت معنی‎داری داشت</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">. در آنالیز رگرسیون لجستیک، متغیرهای جنسیت و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">FEV1</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> اثر معنی</span></span><span dir="LTR" lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">‎</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">داری بر سطح </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">PCT</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar""> داشتند (نسبت</span></span><span dir="LTR" lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">‎</span></span><span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">شانس0/192 و 0/958).</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-BH" style="line-height:92%"><span style="font-family:"B Zar"">پروکلسیتونین در بیماران با تشدید </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">COPD</span></span><span style="line-height:92%"><span style="font-family:"B Zar""> بیشتر از بیماران با تشدید آسم بوده است که نشاندهنده نقش تشدید باکتریایی در </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">COPD</span></span><span style="line-height:92%"><span style="font-family:"B Zar""> میباشد.</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span>
<span style="font-size:12pt"><span style="line-height:145%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:145%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:145%">Serum procalcitonin (PCT) indicates a bacterial infection that can reduce the administration of antibiotics. The aim of this study was to compare serum procalcitonin levels in patients with acute exacerbation of</span></span> <span style="font-size:10.0pt"><span style="line-height:145%">chronic obstructive pulmonary disease (COPD) and asthma and its relationship with lung function and inflammatory factors.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:145%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:145%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:145%">In this cross-sectional study, patients with acute exacerbation of asthma (n= 46) and COPD (n= 23) attending Shahrekord Kashani Hospital were included. After obtaining clinical and demographic information, the participants underwent spirometry and the levels of <span style="letter-spacing:-.1pt">procalcitonin, ESR, white blood cell and PMN counts were determined. Data were analyzed in SPSS V19.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:145%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:145%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:145%">There were significant differences between patients with exacerbation of COPD and asthma in age, sex, ICU hospitalization, and FEV1 percentage (P <0.05) but no significant differences were seen in mean ESR, WBC and PMN (P> 0.05). PCT results in asthma and COPD patients were 8.7% and 56.5%, respectively (P<0.05). Logistic regression analysis showed that gender and FEV1 had significant effects on PCT level (odds ratio 0.192 and 0.958, respectively (P<0.05).</span></span></span></span></span><br>
<b><span style="font-size:10.0pt"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></b> <span style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif"">Procalcitonin in patients with exacerbation of COPD was significantly higher than <span style="letter-spacing:-.1pt">that in patients with exacerbation of asthma, which indicates the role of exacerbation of bacteria in COPD</span></span></span>.
تشدید حاد آسم, بیماری مزمن انسدادی ریه, پروکلسیتونین, ESR, PMN
acute exacerbation of asthma, chronic obstructive pulmonary disease, procalcitonin, ESR, PMN
140
146
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-14848-1&slc_lang=fa&sid=1
Mehdi
Farmani
علی
فرمانی
dr_farmani93@yahoo.com
1003194753284600147628
1003194753284600147628
No
Resident in Internal Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
دستیار داخلی، بیمارستان هاجر، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
Milad
Shahini Shams Abadi
میلاد
شاهینی شمس آبادی
shahini_milad@yahoo.com
1003194753284600147629
1003194753284600147629
No
Assistant Professor, Department of Microbiology, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
استادیار، گروه میکروبیولوژی، مرکز تحقیقات سلولی و مولکولی، پژوهشکده علوم پایه سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
Ali
Ahmadi
علی
احمدی
ahmadiali135824@gmail.com
1003194753284600147630
1003194753284600147630
No
Associate Professor, Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran
دانشیار، گروه اپیدمیولوژی و آمار زیستی، دانشکده بهداشت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
Mohammad-Hassan
Arjmand
محمد حسن
ارجمند
arjmandmh1@gmail.com
1003194753284600147631
1003194753284600147631
No
PhD in Clinical Biochemistry, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
دکترای بیوشیمی بالینی، مرکز تحقیقات سلولی و مولکولی، پژوهشکده علوم پایه سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
Akbar
Soleimai
اکبر
سلیمانی
soleimaniakbar0s@gmail.com
1003194753284600147632
1003194753284600147632
No
Assistant Professor, Department of Internal Medicine, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
استادیار، گروه داخلی، مرکز تحقیقات سلولی و مولکولی، پژوهشکده علوم پایه سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران
Zahra
Habibi Dastenaei
زهرا
حبیبی
dr_Z_habibi@yahoo.com
1003194753284600147633
1003194753284600147633
Yes
Assistant Professor, Department of Internal Medicine, Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
استادیار، گروه داخلی، مرکز تحقیقات سلولی و مولکولی، پژوهشکده علوم پایه سلامت، دانشگاه علوم پزشکی شهرکرد، شهرکرد، ایران