Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
1
admin
1735-9260
1735-9279
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jalali
1401
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2022
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شیوع کمبود آنزیم گلوکز-6-فسفات دهیدروژناز (G6PD) در بیماران مشکوک به فاویسم در شهرستان قلعه گنج در جنوب ایران: یک محدودیت برای حذف مالاریا
Prevalence of Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Patients Suspected of Favism in Qaleh Ganj, Southern Iran: A Restriction for Malaria Elimination
داخلی
Internal medicine
گزارش کوتاه
Brief Report
<strong> </strong><span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">علی</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">رغم مبارزه گسترده با عفونت مالاریا در مناطق آندمیک مالاریا، این بیماری هنوز یکی از جدی</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">ترین بیماری</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">های عفونی در برخی از نقاط جهان است. داروی پریماکین در درمان و پیشگیری مالاریا موثر است. با این حال، افراد مبتلا به کمبود آنزیم </span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">گلوکز-6-فسفات دهیدروژناز (</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="background:white"><span style="line-height:95%"><span style="color:black">G6PD</span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">) هنگام مصرف پریماکین در معرض خطر <span style="letter-spacing:-.1pt">همولیز و عوارض ناشی ازآن می</span></span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt"></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">باشند.</span></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt"> <span style="background:white"><span style="color:black">این مطالعه به منظور تعیین شیوع کمبود آنزیم </span></span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="background:white"><span style="line-height:95%"><span style="color:black"><span style="letter-spacing:-.1pt">G6PD</span></span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"> در بیماران مشکوک به بیماری</span></span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"> فاویسم درشهرستان قلعه گنج در استان کرمان انجام شد.</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">این مطالعه</span></span></span></span> <span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">توصیفی- مقطعی در سال ۱۳۹۹ انجام شد. از تمامی بیماران مشکوک به فاویسم مراجعه</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">کننده به بیمارستان شهدای قلعه گنج در جنوب ایران نمونه خون گرفته شد. فعالیت آنزیم </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="background:white"><span style="line-height:95%"><span style="color:black">G6PD</span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"> توسط تست فلورسانس لکه ای با استفاده از کیت تجاری ارزیابی شد. داده</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">ها با نرم افزار </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="background:white"><span style="line-height:95%"><span style="color:black">SPSS</span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"> نسخه 23 تجزیه و تحلیل شد.</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">در این مطالعه 235 بیمار (88 مرد و 147 زن) مورد بررسی قرار گرفتند. پنجاه و هشت نفر (7/24 درصد) دارای سطحی غیر نرمال (کمبود) از آنزیم </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">G6PD</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""> بودند. 38 نفر (65/6 درصد) از افراد غیر نرمال مبتلا به کمبود شدید و 20 نفر (34/4درصد) مبتلا به کمبود نسبی این آنزیم بودند. ارتباط معنی</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">داری بین جنس و سطح آنزیم یافت نشد (0/96</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P=</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar"">).</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">نتایج مطالعه حاضر شیوع بالای کمبود آنزیم</span></span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="background:white"><span style="line-height:95%"><span style="color:black">G6PD</span></span></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"> را در میان افراد مراجعه</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">کننده به بیمارستان شهرستان قلعه گنج نشان داد، بنابراین لزوم توجه به این موضوع در هنگام تجویز داروهای اکسیداتیو خصوصاً داروهای ضد مالاریا ضروری به نظر می</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="AR-SA" style="background:white"><span style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black">رسد.</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<strong> </strong><span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="background:white"><span style="line-height:150%">Despite wide fight against malaria in endemic regions, it is still one of the most serious infectious diseases in some parts of the world. Primakin is effective in treatment and prevention of malaria.</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"> <span style="background:white">However, individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at risk for hemolysis and its complications when taking primakin.</span> <span style="background:white">This study was performed to <span style="letter-spacing:-.1pt">determine the prevalence of G6PD deficiency in patients suspected of favism in Qaleh Ganj, Kerman, Iran.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:150%">This study was conducted in 2020 and blood </span></span></span><span style="font-size:10.0pt"><span style="line-height:150%">samples were taken from all patients<span style="background:white"> suspicious of favism </span>attending Shohada Hospital in <span style="background:white">Qaleh Ganj, </span>southern Iran<span style="background:white">. </span>The G6PD enzyme activity was evaluated by fluorescent spot test using a</span></span> <span style="font-size:10.0pt"><span style="line-height:150%">commercial kit. Data were analyzed using SPSS V23.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="background:white"><span style="line-height:150%">In this study, 235 patients (88 males and 147 females) were examined. Fifty eight people (24.7%) had abnormal levels (deficiency) of G6PD enzyme, 38 (65.6%) of whom had severe deficiency and 20 (34.4%) had partial deficiency. No significant relationship was found between sex and G6PD level (P= 0.96).</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> <span style="background:white">The study showed a high prevalence of G6PD deficiency in this region. So, attention should be paid to this issue when prescribing oxidative drugs, especially antimalarial drugs.</span><i></i></span></span></span></span></span></span><br>
گلوکز-6 - فسفات دهیدروژناز, مالاریا, قلعه گنج, جنوب ایران
Glucose-6-phosphate dehydrogenase, malaria, Qaleh Ganj, southern Iran
180
185
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-2807-4&slc_lang=fa&sid=1
Mohadeseh
Kamali
محدثه
کمالی
mohadesehkamali.mk@gmail.com
1003194753284600144959
1003194753284600144959
No
Internist, Imam Hospital, Jiroft University of Medical Sciences, Jiroft, Iran
متخصص بیماری های داخلی، بیمارستان امام، دانشگاه علوم پزشکی جیرفت، جیرفت، ایران
Mehdi
Taheri Sarvtin
مهدی
طاهری سروتین
mehditaheri.mt@gmail.com
1003194753284600144960
1003194753284600144960
Yes
Assistant Professor, Department of Medical Mycology and Parasitology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran
استادیار، گروه انگل شناسی و قارچ شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی جیرفت، جیرفت، ایران