Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2022
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بررسی فراوانی آنتی ژن ها ی سازگاری بافتی اصلی کلاس (I)
در جمعیت مازندران
Frequency of Major Histocompatibility Antigens Class I in Mazandaran Province
ايمونولوژي
Immunology
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="FA" style="font-family:"B Zar""><span style="letter-spacing:-.1pt">آنتی</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">ژنهای سازگاری بافتی از پلیمورفترین آنتیژنهای سیستم ایمنی محسوب میشوند. این مطالعه</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> با هدف بررسی فراوانی آنتیژنهای سازگاری بافتی افراد مراجعهکننده به آزمایشگاه </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">HLA</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> در مازندران انجام پذیرفت.<span style="color:#0e101a"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">در این مطالعه توصیفی، از 550 نفر، مراجعهکننده به آزمایشگاه </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">HLA</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> استان مازندران، نمونه خون محیطی تهیه و انواع</span></span> <span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">آنتی ژنهای </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">HLA</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> کلاس یک (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">A-B-C</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">) به روش </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">SSP-PCR</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> تعیین شد.<span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">نتایج حاصل از این مطالعه نشان داد آللهای </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">HLA-A*24</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar"">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">HLA-B*35</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">HLA-C*04</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""> دارای بیشترین فراوانی در جمعیت مورد بررسی بوده است.<span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">تعیین فراوانی آنتی</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">ژن</span><span style="letter-spacing:-.1pt">های </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="letter-spacing:-.1pt">HLA</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt"> در قومیت</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">های مختلف نقش به</span><span style="letter-spacing:-.1pt">سزایی را در ارتباط با بیماری</span><span style="letter-spacing:-.1pt">های مختلف، مطالعات مردم شناسی و یافتن دهنده</span><span style="letter-spacing:-.1pt">ی مناسب در پیوند مغز استخوان ایفا می</span><span style="letter-spacing:-.1pt">کند. لذا انجام مطالعات گسترده</span><span style="letter-spacing:-.1pt">تر در این حوزه حائز اهمیت می</span><span style="letter-spacing:-.1pt">باشد تا بتوان افق جدیدی را در ارتباط </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="letter-spacing:-.1pt">HLA</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt"> با بیماری</span></span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">ها در</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="letter-spacing:-.1pt"> قومیت</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span><span lang="FA" style="font-family:"B Zar""><span style="letter-spacing:-.1pt">های مختلف ترسیم نمود.</span></span><span lang="AR-SA" style="line-height:95%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<strong> </strong><span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">Major histocompatibility antigens </span></span></span><span style="font-size:10.0pt"><span style="line-height:150%">are the most polymorphic components of the immune system. The purpose of this study was to determine the frequency of human leukocyte antigens (HLA) in a population in Mazandaran province, Iran.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">In a cross sectional study, peripheral blood samples were obtained from 550 people in Immunogenetics Research Center affiliated with Mazandaran University of Medical Sciences, 2016-2021. </span></span><span style="font-size:10.0pt"><span style="line-height:150%">The types of HLA class 1 antigens (A-B-C) were studied using SSP-PCR.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">HLA-A * 24, HLA-B * 35 and HLA-C * 04 were found to be the most common alleles in the population studied.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">HLA diversity plays a major role in developing some diseases. So, it should be investigated in anthropological studies and finding a suitable donor in bone marrow transplantation. In fact, more extensive studies are required to draw a new horizon in the association between HLA and diseases in different ethnicities.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br>
فراوانی,آنتی ژن ها ی سازگاری بافتی
frequency, major histocompatibility antigens
135
140
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-13967-2&slc_lang=fa&sid=1
Fatemeh
Toghani Hulari
فاطمه
طغانی هولاری
fatemetoghani@yahoo.com
1003194753284600144181
1003194753284600144181
No
MSc in Immunology, Immunogenetics Research Center, Sari, Iran
کارشناسی ارشد ایمنی شناسی پزشکی، آزمایشگاه HLA، مرکز تحقیقات ایمونوزنتیک، ساری، ایران
Mozhgan
Esmaili
مژگان
اسمعیلی
mozhgan_esmaili@yahoo.com
1003194753284600144182
1003194753284600144182
No
MSc in Immunology, Immunogenetics Research Center, Sari, Iran
کارشناسی ارشد ایمنی شناسی پزشکی، آزمایشگاه HLA، مرکز تحقیقات ایمونوزنتیک، ساری، ایران
Mohammad
Akbari
محمد
اکبری
mhk.333@yahoo.com
1003194753284600144183
1003194753284600144183
No
BSc in Medical Laboratory, Immunogenetics Research Center, Sari, Iran
کارشناسی علوم آزمایشگاهی، آزمایشگاه HLA، مرکز تحقیقات ایمونوزنتیک، ساری، ایران
Fatemeh
Khajenabi
فاطمه
خواجه نبی
fkhajenby@gmail.com
1003194753284600144184
1003194753284600144184
No
MSc in Immunology, Immunogenetics Research Center, Sari, Iran
کارشناسی ارشد ایمنی شناسی پزشکی، آزمایشگاه HLA، مرکز تحقیقات ایمونوزنتیک، ساری، ایران
Saeid
Abediankenari
سعید
عابدیان کناری
abedianlab@yahoo.co.uk
1003194753284600144180
1003194753284600144180
Yes
Professor, Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
استاد، مرکز تحقیقات ایمونوژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران