Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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ارتباط ظرفیت تام آنتی اکسیدانی رژیم غذایی با وضعیت استرس اکسیداتیو در بیماران مبتلا به استئوآرتریت زانو
Relationship between Dietary Total Antioxidant Capacity and Oxidative Stress Markers in Patients with Knee Osteoarthritis
تغذيه
Nutrition
پژوهشي-کامل
Research(Original)
<span style="font-size:12pt"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">با توجه به اهمیت استرس اکسیداتیو در بیماری</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">زایی استئوآرتریت،این مطالعه با هدف بررسی ارتباط بین ظرفیت تام آنتی</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">اکسیدانی رژیم غذایی(</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">DTAC</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">) با نشانگرهای استرس اکسیداتیو در بیماران مبتلا به استئوآرتریت زانو انجام شد.<span style="color:#0e101a"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">در</span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"> این مطالعه مقطعی که </span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">از ماه بهمن سال 1400 تا خرداد سال 1401 اجرا شد</span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">، دریافت غذایی 152 <span style="letter-spacing:-.2pt">بیمار مبتلا به استئوآرتریت</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"> زانو مراجعه</span></span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="letter-spacing:-.2pt"></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">کننده به مراکز درمانی شهر زابل با استفاده از پرسشنامه نیمه کمی بسامد خوراک (</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black"><span style="letter-spacing:-.2pt">FFQ</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">) مورد ارزیابی قرار </span></span></span></span><span lang="FA" style="font-size:11.5pt"><span style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">گرفت. اطلاعات دموگرافیک و تن</span></span></span></span></span><span lang="AR-SA" style="font-size:11.5pt"><span style="line-height:92%"><span style="font-family:"B Zar""><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="FA" style="font-size:11.5pt"><span style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">سنجی هریک</span></span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"> ازشرکت</span></span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="letter-spacing:-.2pt"></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">کنندگان جمع</span></span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="letter-spacing:-.2pt"></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">آوری و </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.2pt">DTAC</span></span></span><span style="line-height:92%"><span style="font-family:"B Zar""><span style="letter-spacing:-.2pt"> <span lang="FA" style="color:black">با روش بررسی توان</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"> آنتی</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">اکسیدانی رژیم غذایی در احیای آهن فریک(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">FRAP</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">) محاسبه شد. سپس غلظت سرمی مالون دی</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">آلدهید(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">MDA</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">)، وضعیت تام اکسیدان سرم(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">TOS</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">)، ظرفیت تام آنتی</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">اکسیدانی سرم(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">TAC</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">) و هم</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">چنین میزان فعالیت آنزیم</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">های آنتی</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">اکسیدان سوپراکسید دیسموتاز(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">SOD</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">)، گلوتاتیون پراکسیداز(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">GPx</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">) و کاتالاز(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">CAT</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">) درگویچه</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">های سرخ به عنوان نشانگرهای استرس اکسیداتیو اندازه</span></span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">گیری شدند. شاخص استرس اکسیداتیو(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">OSI</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black">) نیز با تقسیم میزان </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">TOS</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"> بر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:black">TAC</span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"> محاسبه شد.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">به موازات افزایش </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">DTAC</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">، روند کاهشی معنی</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">داری در غلظت سرمی </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">MDA</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> (001/0</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"B Zar"">></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">-روند)، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">TOS</span></span><span style="line-height:92%"><span style="font-family:"B Zar""> (001/0</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:"B Zar"">></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">-روند) و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">OSI</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> (001/0=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">-روند) و روند افزایشی معنی</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">داری در غلظت سرمی </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">TAC</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> (027/0=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">P</span></span><i><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">-</span></span></i><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">روند) وجود داشت. با این حال، ارتباط آماری معنی</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">داری بین </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">DTAC</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> و میزان فعالیت آنزیمهای آنتی</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">اکسیدانی </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">SOD</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">GPx</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">CAT</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> در گویچه</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">های سرخ مشاهده نشد.<span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">بر اساس یافته</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar"">های مطالعه، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">DTAC</span></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar""> بالاتر بهطور مطلوب با نشانگرهای استرس اکسیداتیو در بیماران مبتلا به استئوآرتریت زانو در ارتباط است. با این حال انجام مطالعات آینده</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">نگر برای تأیید این یافته</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">ها، ضروری به نظر می</span></span><span lang="AR-SA" style="font-family:"B Zar""></span><span lang="FA" style="line-height:92%"><span style="font-family:"B Zar"">رسد.</span></span><span lang="AR-SA" style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:92%"><span style="tab-stops:284.5pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:92%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Considering the pathologic importance of oxidative stress in osteoarthritis (OA), this study aimed to investigate the association between dietary total antioxidant capacity (DTAC) and oxidative stress markers in patients with knee OA.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">In a cross-sectional study, dietary intakes of 152 patients with knee OA</span></span> <span style="font-size:10.0pt"><span style="line-height:150%">attending health centers in Zabol, Iran (January-May 2022) were evaluated using food frequency questionnaire (FFQ). Demographic and anthropometric data were collected and DTAC was calculated using ferric-reducing antioxidant power (FRAP) assay. Then, serum concentrations of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), </span></span><span style="font-size:10.0pt"><span style="line-height:150%">e</span></span><span style="font-size:10.0pt"><span style="line-height:150%">rythrocyte activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured. The oxidative stress index (OSI) was also calculated by dividing TOS by TAC.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">The mean serum concentrations of MDA (P< 0.001), TOS (P-trend< 0.001), and OSI (P-trend= 0.001) showed decreasing trends by increase in</span></span> <span style="font-size:10.0pt"><span style="line-height:150%">DTAC after adjustment for potential confounders. Serum TAC concentrations had increasing trend when DTAC increased (P-trend=0.027).</span></span> <span style="font-size:10.0pt"><span style="line-height:150%">No significant trend was found between erythrocyte activities of SOD, GPx, and DTAC.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> Higher DTAC was favorably associated with oxidative stress markers in patients with knee OA. Further prospective studies are required to confirm these findings.<i></i></span></span></span></span></span></span><br>
ظرفیت تام آنتیاکسیدانی رژیم غذایی, استرس اکسیداتیو, آنزیمهای آنتیاکسیدان, استئوآرتریت
dietary total antioxidant capacity, oxidative stress, antioxidant enzymes, osteoarthritis
128
140
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-15654-1&slc_lang=fa&sid=1
Soudabeh
Hamedi-Shahraki
سودابه
حامدی شهرکی
s.hamedi1@gmail.com
1003194753284600150825
1003194753284600150825
No
Assistant Professor, Department of Epidemiology and Biostatistics, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran
استادیار، گروه اپیدمیولوژی و آمار زیستی، دانشکده بهداشت، دانشگاه علوم پزشکی زابل، زابل، ایران
Farshad
Amirkhizi
فرشاد
امیرخیزی
amirkhizi.f@gmail.com
1003194753284600150826
1003194753284600150826
Yes
Assistant Professor, Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran
استادیار، گروه تغذیه، دانشکده بهداشت، دانشگاه علوم پزشکی زابل، زابل، ایران