Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
1
admin
1735-9260
1735-9279
fa
jalali
1401
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gregorian
2023
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تاثیر عصاره آبی گل بنفشه (Aqueous of Violet) بر میزان تب بیماران کووید- 19: یک کارآزمایی بالینی تصادفی
Effect of Aqueous Extract of Violet on Fever in Patients with COVID-19: A Randomized Clinical Trial
پرستاری
nursing
پژوهشي-کامل
Research(Original)
<span style="font-size:12pt"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="font-family:"B Zar"">گل بنفشه گیاهی است که به دلیل اثرات ضد تب، ضدالتهابی و ضد میکروبی مورد توجه طب </span><span lang="FA" style="font-family:"B Zar"">مکمل </span><span lang="AR-SA" style="font-family:"B Zar"">بوده است. از آن</span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="AR-SA" style="font-family:"B Zar"">جا که تب </span><span lang="FA" style="font-family:"B Zar"">یکی از مهم</span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="font-family:"B Zar"">ترین علائم بیماری</span><span lang="AR-SA" style="font-family:"B Zar""> کووید -19</span> <span lang="FA" style="font-family:"B Zar"">است، </span><span lang="AR-SA" style="font-family:"B Zar"">این مطالعه با هدف تعیین تاثیر عصاره آبی گل بنفشه به صورت شربت بر میزان تب بیماران کووید- </span><span lang="AR-SA" style="font-family:"B Zar"">19</span><span lang="AR-SA" style="font-family:"B Zar""> انجام شد.</span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">در این کارآزمایی بالینی تصادفی، تعداد 52 بیمار مبتلا به کووید-19 از بین بیماران بستری در بخش مراقبت ویژه بیمارستان امام خمینی آمل </span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar"">در سال 1400 </span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">انتخاب شدند. در گروه مداخله علاوه بر آمپول استامینوفن، 5 سی</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">سی از شربت بنفشه باریج تهیه شده از عصاره آبی گل بنفشه نیز استفاده شد. سپس دقیقه 30 و60 و پایان 4 ساعت درجه حرارت درج گردید. تا سه روز پیگیری بیماران ادامه داشت و روند درجه حرارت بیمار هر 6 ساعت ثبت شد.<span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">اختلاف میانگین درجه حرارت نوبت دوم از روز دوم پیگیری در گروه مداخله (37/0</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"Calibri","sans-serif"">± </span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">84/36) و در گروه کنترل (0/62</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"Calibri","sans-serif"">± </span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">37/13) درجه سانتیگراد،</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""> معنیدار بود(0/04=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%">P</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">). هم</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">چنین میانگین درجه حرارت، 30 دقیقه (0/001=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%">P</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">) و 60 دقیقه (0/005=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%">P</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">) بعد از مداخله نیز تفاوت معنی</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">داری نشان داد.</span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">در سایر گروه</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">ها اختلاف آماری معنی</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">داری بین دو گروه مداخله و کنترل وجود نداشت</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%">.</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="letter-spacing:-.1pt">مصرف </span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">عصاره آبی گل بنفشه به صورت شربت موجب کاهش تب بیماران کووید-19 می</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">شود و هیچ</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">گونه عارضه ای در بیماران مشاهده نشد. با توجه به سهولت دسترسی به این فراورده گیاهی، می</span></span><span lang="AR-BH" style="line-height:90%"><span style="font-family:"B Zar"">‎</span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">توان جهت پیشگیری از مشکلات ناشی از تب، تجویز گردد.</span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><b><span dir="LTR" style="font-size:5.0pt"><span style="line-height:90%"></span></span></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"B Zar"">شماره ثبت کارآزمایی بالینی : 6</span></span></span><span dir="LTR" style="font-size:8.0pt"><span style="line-height:90%">N</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"B Zar"">20150916024047</span></span></span><span dir="LTR" style="font-size:8.0pt"><span style="line-height:90%">IRCT</span></span><b><i><span lang="FA" style="font-size:10.0pt"><span style="line-height:90%"><span style="font-family:"2 Davat""></span></span></span></i></b></span></span></span></span></span>
<span style="font-size:12pt"><span style="line-height:125%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:125%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:125%"> Violet is a plant that has received interest in complementary medicine due to its anti-inflammatory, antipyretic, and antimicrobial effects. Fever is one of the major symptoms of COVID-19. This study was conducted to determine the effect of violet extract in the form of syrup on fever in patients with COVID-19.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:125%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:125%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:125%">In this randomized clinical trial, 52 patients with COVID-19 were studied in Intensive Care Unit in Amol Imam Khomeini Hospital (2021). In intervention group in addition to an injection of acetaminophen, 5 cc of violet extract syrup prepared from the aqueous extract of the plant was taken. The temperature was recorded after 30 and 60 minutes and four hours. The follow-up of the patients continued for three days and the temperature was recorded every six hours.</span></span> <span lang="EN" style="font-size:10.0pt"><span style="line-height:125%"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:125%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:125%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:125%">There was a significant difference between the intervention group (36.84±0.37) and control group (37.13±0.62) in mean temperature at second time in second day of follow-up (P=0.04). Also, the mean temperature was found to be significantly different between the two groups at 30 (P=0.001) and 60 minutes (P=0.05) after the intervention. At other groups, there was no significant difference between the intervention and control groups.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:125%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:125%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:125%"> The aqueous extract of violet plant in the form of syrup reduces fever in patients with COVID-19 causing no complication. Due to the ease of access to this herbal product, it can be used to prevent problems caused by fever.<i></i></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:7.0pt"><span style="letter-spacing:-.1pt"></span></span></b></span></span><br>
<span style="font-size:12pt"><span style="font-family:"Times New Roman","serif""><span style="font-size:8.0pt"><span style="letter-spacing:-.1pt">(Clinical Trials Registry Number: </span></span><span style="font-size:8.0pt"><span style="letter-spacing:-.1pt">IRCT20150916024047N6</span></span><span style="font-size:8.0pt"><span style="letter-spacing:-.1pt">)</span></span><b><i><span style="font-size:8.0pt"><span style="letter-spacing:-.1pt"></span></span></i></b></span></span><br>
<br>
بنفشه معطر, درجه حرارت بالا, گیاهان دارویی, کووید- 19
fever, fragrant violet, high temperature, medicinal plants, COVID-19
97
104
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-15297-3&slc_lang=fa&sid=1
Khadije
Omranifar
خدیجه
عمرانی فر
mehravar10261@yahoo.com
1003194753284600150792
1003194753284600150792
No
MSc Student in Critical Care Nursing Student Research Committee, Faculty of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran
دانشجوی کارشناسی ارشد پرستاری مراقبت ویژه، دانشکده پرستاری و مامایی ساری، دانشگاه علوم پزشکی مازندران، ساری، ایران
Hedayat
Jafari
هدایت
جعفری
hjafari@mazums.ac.ir
1003194753284600150793
1003194753284600150793
Yes
Associate Professor, Department of Medical-Surgical Nursing, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
دانشیار، گروه پرستاری داخلی و جراحی، مرکز تحقیقات طب سنتی و مکمل با گرایش اعتیاد، پژوهشکده اعتیاد، دانشگاه علوم پزشکی مازندران، ساری، ایران
Ebrahim
Nasiri Formi
ابراهیم
نصیری فرمی
Nasiri_Formi@YAHOO.COM
1003194753284600150795
1003194753284600150795
No
Assistant Professor, Department of Anesthesiology, Operating Room and Emergencies, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
استادیار، گروه هوشبری، اتاق عمل و فوریتهای پزشکی، مرکز تحقیقات طب سنتی و مکمل با گرایش اعتیاد، پژوهشکده اعتیاد، دانشگاه علوم پزشکی مازندران، ساری، ایران
Rezaali
Mohammadpour Tahamtan
رضاعلی
محمدپور تهمتن
Mohammadpour_TA@YAHOO.COM
1003194753284600150796
1003194753284600150796
No
Professor, Department of Biostatistics and Epidemiology, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran
استاد، گروه آمار زیستی و اپیدمیولوژی، مرکز تحقیقات دیابت، دانشگاه علوم پزشکی مازندران، ساری، ایران
Farhang
Babamahmoodi
فرهنگ
بابامحمودی
FARHANG_12@YAHOO.COM
1003194753284600150794
1003194753284600150794
No
Professor, Department of Infectious Diseases, Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
استاد، گروه عفونی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران