fa بررسی تظاهرات چشمی در بیماران مبتلا به پسوریازیس چشم Eye پژوهشي-کامل Research(Original) <pre dir="RTL" style="margin-right:-3px; text-align:justify; text-indent:.25in"> <span style="font-size:12pt"><span style="line-height:24.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times="">&nbsp;</span></span></span></span><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.2pt">پسوریازیس یک بیماری التهابی مزمن با واسطه ایمنی سیستمیک است که بیش</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.2pt">‌</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.2pt">تر پوست را درگیر می</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.2pt">کند.</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.1pt"> بیماری‌های چشمی که اغلب غیراختصاصی می</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">‌</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.1pt">باشند و تظاهرات کمی در این بیماری از خود نشان می</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">‌</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.1pt">دهند، شناخته شده نیستند. این مطالعه به مقایسه‌ تظاهرات چشمی در بیماران</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.1pt"> مبتلا به</span></span></span><span b="" style="font-family:" zar=""><span style="color:#202124"><span style="letter-spacing:-.1pt"> پسوریازیس و گروه کنترل سالم پرداخته است.</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#0e101a"><span style="letter-spacing:-.1pt"></span></span></span></span></span></span></span></span></span></span></span> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124">در این مطالعه‌ مقطعی </span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar="">که به روش توصیفی-تحلیلی در بیمارستان بوعلی سینا در شهر ساری </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%">)</span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar="">سال 1401-1400) انجام شد، بیماران پسوریازیس و گروه کنترل وارد مطالعه شدند.<span style="color:#202124"> نمرات </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">DLQI</span></span></span><span style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> (شاخص کیفیت زندگی در مبتلایان به بیماری‌های پوستی) و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">PASI</span></span></span><span style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> (شاخص شدت و وسعت پسوریازیس) در گروه مبتلایان به پسوریازیس و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">OSDI</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> (شاخص بیماری سطحی چشم) در هر دو گروه اندازه‌گیری شد. برای هر فرد معاینه توسط لامپ اسلیت، آزمون شیرمر-۱، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">TBUT</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> و فوندوسکوپی انجام گرفت.</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black">در این </span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black">مطالعه، </span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black">۷۵ </span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar="">بیمار مبتلا به پسوریازیس با میانگین سنی 13/88</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:Symbol">&plusmn;</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar="">40/11سال و ۷۵ فرد غیر مبتلا با میانگین سنی 13/55</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="font-family:Symbol">&plusmn;</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar="">39/16 سال مورد بررسی قرار گرفتن</span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar="">د.<span style="color:#202124"> بیماری‌های چشمی مانند </span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black">پرخونی ملتحمه (38/0 درصد)، بلفاریت (36/0 درصد)، اختلال کارکرد غدد میبومین (33/0 درصد) و پینگوکولا (26/0 درصد) در میان بیماران، شایع‌تر بود.</span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black">اختلال کارکرد غدد میبومین</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">TBUT</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124">(زمان شکستن لایه اشکی) پایین در افرادی که نمرات </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">PASI</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">DLQI</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> بالاتری داشتند، بیش‌تر دیده شد. امتیاز </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="color:#202124">OSDI</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124"> نیز در گروه پسوریازیس بالاتر بود که نشان‌دهنده‌ درگیری بیش‌تر گروه بیماران با بیماری خشکی چشم می‌باشد.</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:#202124">درگیری‌های سطحی چشم مانند خشکی چشم در بین بیماران شایع بود و با طول مدت ابتلا و شدت بیماری مرتبط بود. در نتیجه در بیماران پسوریاتیک به منظور تشخیص سریع اختلالات چشمی و جلوگیری از عوارض ناخواسته، باید معاینات چشمی به صورت مکرر و روتین انجام شود.</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span> <span style="font-size:10pt"><span style="line-height:24.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span courier="" new="" style="font-family:"><span dir="LTR" style="font-size:12.0pt"><span b="" style="font-family:" zar=""><span style="color:#202124"></span></span></span></span></span></span></span></span></pre> <span style="font-size:10pt"><span courier="" new="" style="font-family:"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:normal"><span style="text-decoration:none"><span style="line-height:24pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span dir="LTR" style="font-size:12pt"><span b="" nazanin="" style="font-family:"><span style="color:#202124"></span></span></span></span></span></span></span></span></span></span></span></span> <pre dir="RTL" style="text-align:right"> <span style="font-size:10pt"><span courier="" new="" style="font-family:"><span style="color:#000000"><span style="font-style:normal"><span style="font-weight:normal"><span style="text-decoration:none"><span style="line-height:24pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span dir="LTR" style="font-size:12pt"><span b="" nazanin="" style="font-family:"><span style="color:#202124"></span></span></span></span></span></span></span></span></span></span></span></span></pre> <span style="font-size:12pt"><span style="line-height:24.0pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">&nbsp;</span></span></span></b></span></span><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Psoriasis is a systemically pathogenic immune-mediated, chronic inflammatory disease that mostly affects the skin. Ocular diseases, which are frequently nonspecific or just slightly bothersome in psoriasis, are not well-known. This study investigated ocular manifestations in patients with psoriasis.</span></span><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span lang="EN-GB" style="line-height:150%"><span arial="" style="font-family:">Materials and methods:</span></span></b><b> </b><span lang="EN-GB" style="line-height:150%">This cross-sectional study was conducted at Bu-Ali Sina hospital in Sari, Iran. Seventy-five patients with psoriasis matched by age and sex with 75 non-psoriatic controls were examined</span>. <span lang="EN-GB" style="background:white"><span style="line-height:150%"><span style="color:#202124">Dermatology life quality index </span></span></span><span lang="EN-GB" style="line-height:150%">(DLQI) and </span><em><span lang="EN-GB" style="background:white"><span style="line-height:150%"><span style="font-style:normal">psoriasis</span></span></span></em><span lang="EN-GB" style="background:white"><span style="line-height:150%">&nbsp;area and severity index </span></span><span lang="EN-GB" style="line-height:150%">(PASI) scores were calculated for every patient with psoriasis. Ocular surface disease index (OSDI) was measured in both groups. </span><span lang="EN-GB" style="line-height:150%">We did a slit-lamp examination, Schirmer I test, tear breakup time (TBUT) and fundoscopy in both groups.</span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">The mean age of patients was 40.11</span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:Symbol">&plusmn;</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%">13.88 years. The most common findings on our examinations were conjunctival hyperemia (38%), blepharitis (36%), MGD (33%), and pinguecula (26%). MGD and low TBUT were more common in patients with higher PASI and DLQI scores.</span></span> <span style="font-size:10.0pt"><span style="line-height:150%">OSDI score was also higher in patients with psoriasis.</span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Ocular surface conditions such as dry eye were more common among the participants and were correlated with duration and severity of the disease. </span></span><span style="font-size:10.0pt"><span style="line-height:150%">Therefore, psoriasis patients <span style="letter-spacing:-.2pt">should get frequent and routine eye exams to detect ocular disorders quicly and avoid their unintended effects.<i><span style="color:black"></span></i></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:24.0pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"></span></span></span></span> پسوریازیس, چشم, خشکی چشم, تظاهرات چشمی, میبومین psoriasis, eye, dry eye, ocular psoriasis, MGD 77 89 http://jmums.mazums.ac.ir/browse.php?a_code=A-11-15945-1&slc_lang=fa&sid=1 Haniyeh Ghasrsaz حانیه قصرساز h.ghasrsaz@gmail.com 1003194753284600159382 1003194753284600159382 No Medical Student, Bu-Ali Educational, Research and Therapeutic Hospital, Mazandaran University of Medical Sciences, Sari, Iran دانشجوی پزشکی، واحد توسعه تحقیقات بیمارستان بوعلی، دانشگاه علوم پزشکی مازندران، ساری، ایران Reza Jafari رضا جعفری rezaj76@yahoo.com 1003194753284600159383 1003194753284600159383 Yes Assistant Professor, Department of Ophthalmology, Bu-Ali Educational, Research and Therapeutic Hospital, Mazandaran University of Medical Sciences, Sari, Iran استادیار، گروه چشم ‌پزشکی، واحد توسعه تحقیقات بیمارستان بوعلی، دانشگاه علوم پزشکی مازندران، ساری، ایران Zohreh Haj Heydari زهره حاج‌حیدری 1003194753284600159384 1003194753284600159384 No Professor, Department of Dermatology, Bu-Ali Educational, Research and Therapeutic Hospital, Mazandaran University of Medical Sciences, Sari, Iran استاد، گروه پوست، واحد توسعه تحقیقات بیمارستان بوعلی، دانشگاه علوم پزشکی مازندران، ساری، ایران Ghasem Rahmatpour Rokni قاسم رحمت پور رکنی dr.rokni@yahoo.com 1003194753284600159385 1003194753284600159385 No Associate Professor, Department of Dermatology, Bu-Ali Educational, Research and Therapeutic Hospital, Mazandaran University of Medical Sciences, Sari, Iran دانشیار، گروه پوست، واحد توسعه تحقیقات بیمارستان بوعلی، دانشگاه علوم پزشکی مازندران، ساری، ایران