fa اثر هشت هفته تمرین ترکیبی هوازی و مقاومتی بر سطح mir-93، اجزای RCT و لپتین در بیماران پس از عمل جراحی بای پس عروق کرونر فیزیولوژی ورزشی Sport Physiology پژوهشي-کامل Research(Original) <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span b="" koodak="" style="font-family:"><span style="color:black">&nbsp;</span></span></span></span></span></span></span><span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">بیماری‌های قلبی عروقی علت اصلی مرگ و میر در کل دنیا است و 82 درصد این مرگ و میرها در کشورهای در حال توسعه است. </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">mir-93</span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">(</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">MicroRNA-93)</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">(</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">ATP-binding cassette transporters A1) </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">ABCA1</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و لپتین ممکن است در ایجاد آترواسکلروز دخیل باشند. هدف از این مطالعه <span style="letter-spacing:-.1pt">بررسی اثر هشت هفته تمرین ترکیبی بر</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">mir-93</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">، اجزای </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">(</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">Reverse cholesterol transport</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">) RCT</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و لپتین در بیماران پس از عمل جراحی بای پس بود.</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">تعداد 20 مرد میانسال (50 الی 60 سال) پس از عمل </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">(</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">Coronary artery bypass surgery</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">) CABG</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> به‌طور تصادفی در دو گروه کنترل (10 نفر) و تجربی (10 نفر) قرار گرفتند. 8 هفته تمرین ترکیبی (هوازی + مقاومتی) شامل 3 جلسه در هفته و هر جلسه 55 الی 60 دقیقه بود. قبل و بعد از این دوره تمرینی </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">mir-93</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">ABCA1</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و لپتین مورد اندازه‌گیری قرار گرفتند. از آزمون تی همبسته برای بررسی تغییرات درون گروهی و از آزمون کوواریانس برای بررسی تغییرات بین گروهی استفاده شد.</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">تمرین ترکیبی منجر به کاهش معنی‌دار </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">mir-93</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> (0/000=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">) </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">افزایش معنی دار </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">ABCA1</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> (0/001=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">). </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">در گروه تجربی در مقایسه با گروه کنترل شد. در گروه تمرین، لپتین به‌طور معنی‌داری کاهش پیدا کرد (0/000=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">) </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">اما تفاوت بین گروهی لپتین معنی‌دار نبود (0/094=</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">)</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">.</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">به نظر می‌رسد تمرین ترکیبی از طریق افزایش </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">ABCA1</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و کاهش </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">mir-93</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و لپتین بتواند در پیشگیری و کنترل بیماری‌های قلبی عروقی و نیز در تسریع روند بهبودی در بیماران </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">CABG</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> مفید باشد.<span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:11pt"><span style="line-height:200%"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:10.0pt"><span style="line-height:200%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">&nbsp;</span></span></span></span></b></span></span></span></span><span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">Cardiovascular diseases </span></span><span style="font-size:10.0pt"><span style="line-height:150%">(CVDs) are the leading cause of death worldwide that account for 82% of all deaths in developing countries. miRNA-93 (miR-93), ATP-binding cassette transporter A1 (ABCA1), and serum leptin levels may be involved in the process of atherosclerosis. The aim of this study was to investigate the effects of combined exercise on miR-93, reverse cholesterol transport (RCT) and serum leptin levels in patients following coronary artery bypass graft surgery (CABG).</span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">A total of 20 middle-aged men (aged 50 to 60 years) were randomly assigned into two groups after CABG: experimental (n=10) and control (n=10). Combined exercise (aerobic + resistance) was done three times a week (55-60 min per session/8 weeks). mir-93, ABCA1 and serum leptin levels were measured before and after the intervention. Paired t-test was used to evaluate within group changes and analysis of covariance was used to study the differences between the groups.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">Combined training led to a significant decrease in mir-93 (P=0.000) and a significant increase in the expression of ABCA1 (P=0.001) in experimental group compared with the control group. Serum leptin levels decreased significantly in experimental group (P=0.000) but they were not significantly different between the two groups (P=0.094).</span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> It seems that combined exercise by increasing ABCA1and decreasing mir-93 and leptin levels can help in prevention and control of CAD as well as speeding up the healing process in CABG patients.<i></i></span></span></span></span></span></span><br> &nbsp; mir-93, ABCA1, لپتین, CABG, تمرین ترکیبی mir-93, ABCA1, leptin, CABG, combined training 12 22 http://jmums.mazums.ac.ir/browse.php?a_code=A-11-16083-1&slc_lang=fa&sid=1 Fahime Sadat Jamali فهیمه سادات جمالی fasaja88@yahoo.com 1003194753284600154894 1003194753284600154894 No PhD Student in Sport Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran دانشجوی دکتری فیزیولوژی ورزشی، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران Amir Rashidlamir امیر رشیدلمیر rashidlamir@um.ac.ir 1003194753284600154895 1003194753284600154895 Yes Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran دانشیار، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران Seyyed Reza Attarzadeh Hosseini سیدرضا عطارزاده حسینی attarzade.hosseini@um.ac.ir 1003194753284600154896 1003194753284600154896 No استاد، گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه فردوسی مشهد، مشهد، ایران