Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2023
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سطح سرمی سلنیوم در بیماران مبتلا به آفت راجعه دهانی
Serum Levels of Selenium in Patients with Recurrent Aphthous Stomatitis
دندانپزشکی
Dentistry
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"> </span></span></span></span></span></span></span><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <a name="_Hlk121222118"><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">آفت راجعه دهانی </span></span></span></a><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">یکی از شایعترین زخمهای عودکننده در مخاط دهان میباشد که پاتوژنز آن بهطور دقیق مشخص نشده است. به نظر م</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">ی</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">رسد اختلال در پاسخ ایمنی و استرس اکسیداتیو نقش مهمی در این بیماری دارد</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">.</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> با توجه به اینکه سلنیوم نقش تنظیمکننده در </span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">سیستم </span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">ایمنی و استرس اکسیداتیو دارد، هدف ازاین مطالعه بررسی سطح سرمی سلنیوم در بیماران مبتلا به استوماتیت آفتی راجعه و مقایسه آن با افراد سالم میباشد.</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">این مطالعه مورد- شاهدی در</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> دانشکده دندانپزشکی بابل</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> انجام شد. 50 نفر در گروه مبتلایان به آفت راجعه دهانی قرار گرفتند و 53 نفر فرد سالم که از نظر سن و جنس با گروه مورد همسان شدند، برای گروه کنترل انتخاب شدند. نمونه خون از هر دو گروه گرفته شد. سطح سرمی سلنیوم اندازهگیری شد</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">.</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> دادهها توسط نرمافزار 17 </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">SPSS</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> و آزمونهای </span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">آماری </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">Independent Sample t Test</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> و </span></span></span><a name="_Hlk121238014"><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">chi-square Tests</span></span></span></a> <span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مورد تجزیه و تحلیل قرار گرفت<a name="_Hlk121783458">. </a></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">میانگین سنی گروه شاهد و مبتلا به آفت به ترتیب 8/21</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">±</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">34/77و 9/69</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">±</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">37/68 سال بود. زنان در گروه کنترل و مبتلا به آفت به ترتیب 67/9و 74 درصد افراد را تشکیل دادند. میانگین سطح سرمی سلنیوم در گروه کنترل (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">µg/L</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">17/03</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">±</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">49/16</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">) نسبت به گروه مبتلا به آفت (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">µg/L</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> 17/74</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">±</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">31/09</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">)، بهطور معنیداری بیشتر بود(</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">0/001</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">P<</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">).</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">استنتاج:</span></span></span> <span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">بر اساس مطالعه حاضر سطح سرمی سلنیوم در بیماران مبتلا به آفت راجعه دهانی کم</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">تر از افراد سالم می</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"></span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">باشد.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt"> </span></span></span></span></b></span></span></span></span><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <a name="_Hlk121237731"><span style="font-size:10.0pt"><span style="line-height:150%">Recurrent aphthous stomatitis </span></span></a><span style="font-size:10.0pt"><span style="line-height:150%">(RAS) is one of the most common recurrent ulcers in the oral mucosa and its etiology is not yet elucidated, but the immune system dysfunction and oxidative stress may play a role in the pathogenesis of RAS. Selenium has regulatory role in the immune system and oxidative stress. This study aims to compare serum levels of selenium between patients with RAS and healthy controls.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">This case-control study was performed in 50 patients with minor RAS and 53 healthy controls that were matched for age and sex. Blood samples were obtained from all participants and selenium serum levels were measured. Data were analyzed in SPSS V17 applying independent sample t-test and Chi-square. </span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">The average age of the controls and case group was 34.77±8.21 and 37.68±9.69 years, respectively and women included 67.9% and 74%, respectively .The mean serum level of <a name="_Hlk121237744">selenium</a> in the control group (49.16±17.03 <a name="_Hlk121238175">µg/L</a>) was significantly higher than that of the case group (31.09±17.74µg/L) (P<0.001).</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Serum levels of selenium are lower in patients with RAS than healthy controls.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"><span style="color:black"></span></span></span></i></span></span></span></span><br>
آفت راجعه دهانی, سلنیوم, سیستم ایمنی, استرس اکسیداتیو
recurrent aphthous stomatitis, selenium, immune system, oxidative stress
138
143
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-7740-3&slc_lang=fa&sid=1
Fatemeh
Jafari
فاطمه
جعفری
F.jafari519@gmail.com
1003194753284600158040
1003194753284600158040
No
Dentistry Student, Student Research Committee, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran
دانشجوی دندانپزشکی، کمیته تحقیقات دانشجویی، دانشکده دندانپزشکی، دانشگاه علوم پزشکی بابل، بابل، ایران
Atena
Shirzad
آتنا
شیرزاد
ats60dent@gmail.com
1003194753284600158041
1003194753284600158041
Yes
Associate Professor, Department of Oral and Maxillofacial Medicine, Oral Health Research Center, Babol University of Medical Sciences, Babol, Iran
دانشیار، گروه بیماری های دهان، فک و صورت، مرکز تحقیقات سلامت و بهداشت دهان ، دانشگاه علوم پزشکی بابل، بابل، ایران
Hadi
Parsian
هادی
پارسیان
hadiparsian@yahoo.com
1003194753284600158044
1003194753284600158044
No
Professor, Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
استاد، گروه بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی بابل، بابل، ایران
Ali
Bijani
علی
بیژنی
alibijani@yahoo.com
1003194753284600158043
1003194753284600158043
No
Assistant Professor, Social Determinants of Health Research Centre, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
استادیار، مرکز تحقیقات عوامل اجتماعی موثر بر سلامت، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل، بابل، ایران
Abbas
Mosapour
عباس
موسی پور
ab_mspr@yahoo.com
1003194753284600158042
1003194753284600158042
No
PhD in Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
دکترای بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی بابل، بابل، ایران