fa بررسی گزارش‌های ارسال شده در زمینه عوارض ناخواسته داروها در مراکز تحت پوشش دانشگاه علوم پزشکی مازندران از سال 1398 تا 1400 داروسازی Pharmacy پژوهشي-کامل Research(Original) <span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:11.0pt"><span style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black">&nbsp;</span></span></span></span></span></span></span></span><span style="line-height:94%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span> <span b="" style="font-family:" zar="">عوارض جانبی داروها یکی از عوامل مهم تهدیدکننده حیات و کیفیت زندگی بوده و می</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">تواند سبب تحمیل هزینه</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">های زیادی به سیستم</span> <span b="" style="font-family:" zar="">بهداشتی و درمانی یک کشور شود.</span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"> این مطالعه در معاونت غذا و داروی دانشگاه علوم پزشکی مازندران با هدف </span></span></span><span b="" style="font-family:" zar="">بررسی عوارض ناخواسته دارویی در استان انجام شد.</span><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:94%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span> <span b="" style="font-family:" zar="">این</span> <span b="" style="font-family:" zar="">مطالعه توصیفی گذشته</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">نگر، پس از جمع</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">آوری گزارش</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">های ارسالی کارت زرد به مرکز ثبت و بررسی عوارض جانبی ناخواسته دارویی در معاونت غذا و دارو مازندران و گزارش</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">های ثبت شده در سامانه آنلاین ثبت عوارض و اشتباهات داروپزشکی، در سال</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">های 1398 تا 1400 صورت گرفت. آنالیز</span> <span b="" style="font-family:" zar="">بر مبنای</span> <span b="" style="font-family:" zar="">فراوانی</span> <span b="" style="font-family:" zar="">داروی</span> <span b="" style="font-family:" zar="">عارضه</span> <span b="" style="font-family:" zar="">داده،</span> <span b="" style="font-family:" zar="">فراوانی نحوه </span>&nbsp;<span b="" style="font-family:" zar="">مصرف دارو، تعداد گزارش در هر سال، مشخصات</span> <span b="" style="font-family:" zar="">بیمار</span><span b="" style="font-family:" zar=""> (رده‌ سنی</span> <span b="" style="font-family:" zar="">و جنسیت)، هم</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">چنین فراوانی سیستم</span> <span b="" style="font-family:" zar="">و عضو آسیب دیده و گزارشگر صورت گرفت.</span><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:94%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:94%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">در مجموع تعداد 2122 مورد گزارش به معاونت غذا و داروی مازندران ارسال شده بود. 52/78 درصد از گزارشات توسط پرستاران اعلام شده است و </span></span><span lang="FA" style="line-height:94%"><span b="" style="font-family:" zar="">44/82</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""> درصد عوارض جانبی ثبت شده در زنان رخ داده است. بیش</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">ترین فراوانی عوارض جانبی را، فرم تزریقی (87/40 درصد) به خود اختصاص داد و هم</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">چنین طبق نتایج به</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">دست آمده، بیش</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">ترین عوارض ثبت شده مربوط به اختلالات پوست و مو (28/07 درصد) می</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">باشد. شایع</span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar="">ترین دسته دارویی مسبب عارضه نیز، </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:94%"><span style="font-family:BZar">Anti-Infective Agents</span></span></span><span style="line-height:94%"><span b="" style="font-family:" zar=""> (47/10 درصد) بوده‌اند و داروی </span></span><span lang="FA" style="line-height:94%"><span b="" style="font-family:" zar="">ونکومایسین در صدر قرار داشت.</span></span><span lang="FA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:94%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span> <span b="" style="font-family:" zar="">با توجه به تعداد</span> <span b="" style="font-family:" zar="">مطلوب ثبت و ارسال گزارش عوارض ناخواسته دارویی در استان مازندران، به نظر می</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">رسد با برگزاری کلاس</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">های آموزشی جهت گروه هدف پزشکی و سایر کادر درمان با محوریت آموزش فارماکوویژیلانس و نحوه گزارش</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">دهی آن، به استانداردهای جهانی نزدیک</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">تر شده</span><span lang="AR-SA" style="line-height:94%"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar="">ایم.</span><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Adverse drug reaction (ADR) is one of the main causes of mortality and morbidity and can contribute to high costs in healthcare system of a country. This study was conducted to evaluate ADRs in the Food and Drug deputy at Mazandaran University of Medical Sciences.</span></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">This retrospective descriptive study was carried out after collecting the reports of yellow cards sent to the Center for Registration and Investigation of Adverse Drug Reaction in the Food and Drug Deputy of Mazandaran and the reports registered in the online system for registering medical complications and errors in 2019-2021. We analyzed data, including the frequency of the drugs with side effects, the frequency of routs of administration, number of reports per year, patient characteristics (</span></span><span style="font-size:10.0pt"><span style="line-height:150%">gender and</span></span><span style="font-size:10.0pt"><span style="line-height:150%"> age), as well as the frequency of the organs damaged, and the reporters.</span></span></span></span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">A total of 2122 reports of adverse drug reactions were submitted to the Adverse Drug Reactions Center at Mazandaran Food and Drug Department. Nurses reported 52.78% of the side effects and 44.82% of the ADRs were seen in women. Injectable drugs were found with high rate of ADRs (87.40%) and the most prevalent side effects were associated with skin and hair disorders (28.07%). Anti-infective agents were the most common drugs that caused ADR (47.10%) and Vancomycin was found to be more prevalent than other drugs.</span></span></span></span></span><br> <span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> Adverse drug reactions were reported at a good level in Mazandaran province. It is believed that training the medical staff about pharmacovigilance and appropriate reporting, will bring us closer to world standards.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br> <span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">&nbsp;</span></span></span></span></b></span></span></span></span></span><span style="font-size:10pt"><span style="background:#f8f9fa"><span style="line-height:115%"><span style="font-family:Consolas"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span> فارماکوویژیلانس, عوارض ناخواسته دارویی, کارت زرد pharmacovigilance, adverse drug reaction, yellow Card 101 108 http://jmums.mazums.ac.ir/browse.php?a_code=A-10-4456-5&slc_lang=fa&sid=1 Mina Amini مینا امینی drminaamini@yahoo.com 1003194753284600159386 1003194753284600159386 Yes Doctor of Pharmacy, Research and Development Office, Food and Drug Deputy, Mazandaran University of Medical Sciences, Sari, Iran دکتر داروساز، دفتر تحقیق و توسعه، معاونت غذا و دارو، دانشگاه علوم پزشکی مازندران، ساری، ایران Arefeh Mirzaei Ilali عارفه میرزائی ایلالی arefehmirzaei76@gmail.com 1003194753284600159387 1003194753284600159387 No Doctor of Pharmacy, Research and Development Office, Food and Drug Deputy, Mazandaran University of Medical Sciences, Sari, Iran دکتر داروساز، دفتر تحقیق و توسعه، معاونت غذا و دارو، دانشگاه علوم پزشکی مازندران، ساری، ایران Fatemeh Mahmoudi فاطمه محمودی fatemehmhmdi70@gmail.com 1003194753284600159388 1003194753284600159388 No Doctor of Pharmacy, Research and Development Office, Food and Drug Deputy, Mazandaran University of Medical Sciences, Sari, Iran دکتر داروساز، دفتر تحقیق و توسعه، معاونت غذا و دارو، دانشگاه علوم پزشکی مازندران، ساری، ایران