Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2023
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بررسی ویژگیهای کلینکی مبتلایان به زونا بر حسب سن در شهرستان ساری
Clinical Features of Patients with Herpes zoster According to Age, in Sari, Iran
ويروس شناسي پزشکي
Medical Virology
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"> </span></span></span></span></span></span></span><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری زونا در افراد مسنتر، بیشتر بروز پیدا میکند که شناخته شدهترین علل آن کاهش عملکرد سیستم ایمنی بدن و وجود بیماریهای زمینهای در این افراد میباشد. این مطالعه با هدف بررسی ویژگیهای کلینیکی مبتلایان به زونا بر حسب سن در شهرستان ساری، انجام پذیرفت.</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:#0e101a"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">در این مطالعه</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar"">توصیفی- تحلیلی گذشتهنگر، <span style="color:black">افراد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مورد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مطالعه</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">شامل</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">کلیه</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماران بستری یا تحت درمان سرپایی، با</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">تشخیص</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">زونا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">در</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">سالهای ۹۷-۹۵ در بیمارستانهای ساری که</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">اطلاعات</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">پروندهای</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">آنها</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">کامل بوده است، میباشد. اطلاعات به صورت</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">سرشماری</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">و با بهرهگیری از اطلاعات</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">موجود پروندههای</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بایگانی، جمعآوری گردید.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">تعداد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماران</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">وارد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">شده</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مطالعه</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">180</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بودند که گروهبندی افراد براساس سن آنها صورت گرفت. در افراد زیر ۵0</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">سال</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">۹۷</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">زمینهای</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">خاصی</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نداشتند، 6 نفر مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">دیابت</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بودند 4 نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به فشارخون، 3</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به بدخیمی و 12</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">قلبی</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">عروقی</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بودند. در</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">افراد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بالای</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">۵0</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">سال نیز 21 نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">فاقد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری زمینهای،</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">15</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر مبتلا به دیابت، 2 نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">فشارخون، 11</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بدخیمی</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">و</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">۹</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نفر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری قلبی</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">عروقی بودند. وجود بیماری زمینهای در بیماران مبتلا به بدخیمی و دیابت بالای پنجاه سال مبتلا به زونا بهطور معناداری از افراد زیر 50 سال بالاتر بوده است(0/042</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">P=</span></span></span><span style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"> و 0/05</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">P=</span></span></span><span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">).</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:90%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">با</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">توجه</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">ریسک</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">فاکتورهای</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مطرح</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">شده</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">در</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">این</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">مطالعه و مخصوصا در افراد مسن،</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">در</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">افراد مبتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری زمینهای یا افرادی که داروهای سرکوبکننده سیستم ایمنی مصرف میکنند، باید با دقت بیشتری تحت</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">نظر</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">گرفته شوند و</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">محض</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">ابتلا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بیماری</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">درمان</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">به</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">سرعت</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">آغاز</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">شود</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">تا</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">از</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">بروز عوارض</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">شدید</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">آن</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">در</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">این</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">افراد</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">جلوگیری</span></span></span> <span lang="FA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black">شود</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:90%"><span style="color:black">.</span></span></span><span lang="AR-SA" style="line-height:90%"><span style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt"> </span></span></span></span></b></span></span></span></span><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Reduced function of immune system and underlying diseases make older people more susceptible to Shingles (herpes zoster). The present study aimed to compare the clinical findings and underlying conditions between patients with herpes zoster under 50 years and over 50 years of age.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">T</span></span><span style="font-size:10.0pt"><span style="line-height:150%">his cross-sectional descriptive study included all patients who were admitted or hospitalized in Sari hospitals due to herpes zoster in 2016-2018 with complete medical records. Information was collected by census. </span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">There were 180 cases who were investigated according to their age. In patients under 50 years of age, 97 had no underlying diseases, while diabetes, hypertension, malignancy, and cardiovascular diseases were seen in 6, 4, 3, and 12 patients, respectively. In patients over 50 years of age, 21 were found with no underlying diseases, but 15, 2, 11, and 9 cases had diabetes, hypertension, different types of malignancies, and cardiovascular diseases, respectively. The frequency of underlying diseases in patients with cancer and diabetes in patients with herpes zoster were significantly higher in people over 50 years of age (P= 0.042 and P= 0.05). </span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">Given the risk factors presented in this study, patients with underlying diseases or those on immunosuppressive drugs are required to be closely monitored and receive early treatments as soon as developing herpes zoster to avoid severe complications. </span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br>
واریسلا زوستر, زونا, بیماری زمینهای
Varicella zoster virus, herpes zoster, underlying diseases
166
170
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-1466-148&slc_lang=fa&sid=1
Lotfollah
Davoodi
لطف اله
داودی
lotfdavoodi@yahoo.com
1003194753284600155810
1003194753284600155810
No
Associate Professor, Antimicrobial Resistance Research Center, Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran
دانشیار، مرکز تحقیقات مقاومتهای میکروبی، گروه عفونی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Tahoora
Mousavi
طهورا
موسوی
stm.jmums@gmail.com
1003194753284600155811
1003194753284600155811
No
Assistant Professor, Molecular and Cell Biology Research Center (MCBRC), Hemoglobinopathy Institute, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
استادیار، مرکز تحقیقات سلولی مولکولی، پژوهشکده هموگلوبینوپاتی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Mahsa
Hasanabadi
مهسا
حسن آبادی
Mahsa.hassanabadi@gmail.com
1003194753284600155812
1003194753284600155812
No
Medical Student, Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran
دانشجوی پزشکی، مرکز تحقیقات مقاومت های میکروبی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Hossein
Jalali
حسین
جلالی
Hossein.jalaliakerdi@gmail.com
1003194753284600155813
1003194753284600155813
Yes
Assistant Professor, Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran
استادیار، مرکز تحقیقات تالاسمی، دانشگاه علوم پزشکی مازندران، ساری، ایران