Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
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تأثیر تمرین پیلاتس همراه با رزوراترول بر سطوح GRP78 و
TRB3 سرمی در زنان میانسال چاق شهر تهران
Effect of Pilates Training and Resveratrol on Serum Levels of Endoplasmic Reticulum Stress Indicators in Middle-Aged Obese Women in Tehran
فیزیولوژی ورزشی
Sport Physiology
پژوهشي-کامل
Research(Original)
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span b="" lang="FA" style="font-family:" zar=""> </span></span></span></span><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">اختلال در هومئوستاز شبکه آندوپلاسمی</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""> (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">ER</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""> ) </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">به عنوان یکی از ویژگیهای بارز چاقی شناخته شده است. ترکیب رژیم غذایی با فعالیت ورزشی میتواند سلامتی و عملکرد را بهبود بخشد. این مطالعه با هدف بررسی تأثیر <span style="letter-spacing:-.1pt">تمرینات پیلاتس(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="letter-spacing:-.1pt">PT</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">) و رزوراترول</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="letter-spacing:-.1pt">RSV</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">) </span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">بر شاخصهای استرس شبکه آندوپلاسمی در زنان میانسال چاق، انجام پذیرفت</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="letter-spacing:-.1pt">.</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:#0e101a"><span style="letter-spacing:-.1pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">در این مطالعه کارآزمایی بالینی،</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""> با کد </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">IRCT20140415017288N11</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">، 40 زن بالغ چاق (سن 5/70</span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:95%">±</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">42/74 سال، شاخص تودهبدنی 1/37</span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:95%">±</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">31/76 کیلوگرم بر متر مربع) از شهر تهران انتخاب و بهطور تصادفی به چهار گروه دارونما (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">C</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">)، تمرین پیلاتس (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">PT</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">)، رزوراترول (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">RSV</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">) و تمرین پیلاتس- رزوراترول (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">PTRSV</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">) تقسیم</span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">شدند. گروههای </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">PT</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> برنامه تمرینی با 16-14 </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">RPE</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> را به مدت 8 هفته، 3 بار در هفته انجام دادند. به گروههای </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">RSV</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">PTRSV</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> قرصهای 500 میلیگرمی </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">RSV</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> در </span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">هر روز </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">صبح داده شد. دادهها با استفاده از آزمون </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">t</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> همبسته و آنکوا تحلیل شد.</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="letter-spacing:-.2pt">یافته</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.2pt"></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="letter-spacing:-.2pt">ها:</span></span></span> <span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">در این مطالعه </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">نشان داده شد که</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"> PT </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">و</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"> RSV </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">باعث کاهش</span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">پروتئین تنظیمکننده گلوکز 78 (</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">GRP78</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">)</span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">(0/001</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P=</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و 0/007</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P=</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">) و </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">همولوگ 3 تریبلس</span></span> <span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">(</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">TRB3</span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar="">) </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">(0/0001</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P=</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> و 0/0001</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P=</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">) شدند.</span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">مداخله همزمان</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"> PT </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">و</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"> RSV </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">نیز باعث کاهش</span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">GRP78</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">TRB3</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> نسبت به سایر گروهها شد (0/05</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">P<</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">).</span></span><span lang="FA" style="line-height:95%"><span style="font-family:"B Zar""></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">مکمل</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"> PT </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">و</span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"> RSV </span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar="">میتواند استرس شبکه آندوپلاسمی را در زنان میانسال چاق با تغییر سطوح </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">GRP78</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> و </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">TRB3</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""> بهبود بخشد. اما اثر همزمان </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">PT</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> با </span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%">RSV</span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""> بر این شاخصها بهتر بود.</span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span dir="LTR" style="font-size:5.0pt"><span style="line-height:95%"></span></span></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="font-size:10.0pt"><span style="line-height:95%"><span b="" style="font-family:" zar="">شماره ثبت کارآزمایی بالینی : 11</span></span></span><span dir="LTR" style="font-size:8.0pt"><span style="line-height:95%">N</span></span><span lang="FA" style="font-size:10.0pt"><span style="line-height:95%"><span b="" style="font-family:" zar="">201404151017288</span></span></span><span dir="LTR" style="font-size:8.0pt"><span style="line-height:95%">IRCT</span></span><b><i><span lang="FA" style="font-size:10.0pt"><span style="line-height:95%"><span style="font-family:"2 Davat""></span></span></span></i></b></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span arial="" style="font-family:"><span style="color:red"><span style="letter-spacing:-.2pt"> </span></span></span></span></b></span></span></span><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <a name="_Hlk127627360"><span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">Perturbation of the endoplasmic reticulum (ER) homeostasis is known as one of the prominent features of obesity. Combining a healthy diet and exercise can improve health and performance. The aim of this study was to </span></span></span></a><a name="_Hlk85708452"><span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">investigate </span></span></span></a><span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">the effect of Pilates training (PT) and resveratrol (RSV) on endoplasmic reticulum stress indicators in middle-aged obese women.</span></span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">In this clinical trial, 40 obese adult women with the mean age of 42.74±5.70 years and body mass index of 31.76±1.37 kg/m2 in Tehran were randomly allocated into four groups; Placebo (C), Pilates Training (PT), Resveratrol (RSV), and Pilates Training-Resveratrol (PTRSV). The PT groups did the training program with 14-16 RPE for 8 weeks, 3 times/week. The RSV and PTRSV groups were provided with 500 mg RSV tablets every morning. Data were analyzed using independent t-test and ANCOVA.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">According to findings, PT and RSV decreased</span></span></span> <span style="font-size:10.0pt"><span style="line-height:150%"><span style="letter-spacing:-.2pt">Glucose-regulating protein 78 (GRP78) (P=0.001 and P=0.007, respectively) and Tribbles homolog 3 (TRB3) (P=0.0001 and P=0.0001, respectively). Simultaneous intervention of PT and RSV also reduced GRP78 and TRB3 more than other groups (P<0.05).</span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> <span style="letter-spacing:-.2pt">PT and RSV supplementation could improve the endoplasmic reticulum stress in middle-aged obese women by altering the levels of GRP78 and TRB3. However, the simultaneous effect of PT and RSV was found to be better on these indices.</span><i></i></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:7.0pt"><span style="line-height:150%"><span style="letter-spacing:-.1pt"></span></span></span></b></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="font-size:8.0pt"><span style="line-height:150%"><span style="letter-spacing:-.1pt">(Clinical Trials Registry Number: </span></span></span><span style="font-size:8.0pt"><span style="line-height:150%"><span style="letter-spacing:-.1pt">IRCT20140415017288N11</span></span></span><span style="font-size:8.0pt"><span style="line-height:150%"><span style="letter-spacing:-.1pt">)</span></span></span><b><i><span style="font-size:8.0pt"><span style="line-height:150%"><span style="letter-spacing:-.1pt"></span></span></span></i></b></span></span></span><br>
فعالیت ورزشی, رزوراترول, استرس شبکه آندوپلاسمی, چاقی
exercise, resveratrol, endoplasmic reticulum stress, obesity
57
70
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-8936-3&slc_lang=fa&sid=1
Nina
Alipour Ghazichaki
نینا
علیپور قاضی چاکی
Nina_alipour@yahoo.com
1003194753284600157180
1003194753284600157180
No
PhD Student in Exercise Physiology, Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
دانشجوی دکتری، گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران
Ahmad
Abdi
احمد
عبدی
a.abdi58@gmail.com
1003194753284600157181
1003194753284600157181
Yes
Associate Professor, Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
دانشیار، گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران
Alireza
Barari
علیرضا
براری
alireza54.barari@gmail.com
1003194753284600157182
1003194753284600157182
No
Associate Professor, Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
دانشیار، گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران