Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2023
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بررسی میزان آنتی اکسیدانهای بزاق در بیماران مبتلا به آبسه حاد اپیکال، قبل و بعد از درمان ریشه
Salivary Antioxidants in Patients with Acute Apical Abscess before and after Root Canal Treatment
دندانپزشکی
Dentistry
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span b="" koodak="" style="font-family:"><span style="color:black"> </span></span></span></span></span><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">آنتیاکسیدانها میتوانند از آسیب اکسیداتیو ناشی از افزایش تولید رادیکالهای آزاد در بیماریهای دهان و دندان جلوگیری کنند. در این مطالعه به بررسی میزان ظرفیت کلی آنتیاکسیدان (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">TAC</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">) بزاق در بیماران مبتلا به آبسه حاد اپیکال، قبل و بعد از درمان ریشه و مقایسه آن با گروه کنترل پرداخته شده است.</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">در این مطالعه مورد- شاهدی، نمونه برداری از میزان آنتیاکسیدان بزاق 20 نفر از بیماران مبتلا به آبسه</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> حاد اپیکال، قبل و سه هفته بعد از درمان ریشه انجام شد. علاوه بر این 20 فرد سالم (فاقد پوسیدگی و آبسه دندانی و بدون داشتن بیماریهای سیستمیک)، بهعنوان گروه کنترل در نظر گرفته شد.</span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">برای اندازهگیری میزان آنتیاکسیدان <span style="letter-spacing:-.2pt">نمونههای بزاق از روش توانایی پلاسما در احیای یونهای فریک(</span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black"><span style="letter-spacing:-.2pt">FRAP</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">) استفاده و </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black"><span style="letter-spacing:-.2pt">TAC</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"> نمونهها ارزیابی شد. سپس تمامی</span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> دادهها جمعآوری و آنالیز آماری با استفاده از آزمون آماری </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">T-test</span></span></span><span style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> و نرمافزار </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">SPSS</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> نسخه 16 انجام شد.</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">میزان </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">TAC</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> بزاق افراد در گروه مورد قبل از درمان برابر</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">µmol/L</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> 174/9</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">±</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">298/8 و بعد از درمان برابر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">µmol/L</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> 145/2</span></span></span><span lang="AR-SA" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">±</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">450</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">/9 حاصل شد، که این افزایش از نظر آماری معنیدار بود(0/009=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">P</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">). اما </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">TAC</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"> گروه مورد پس از درمان ریشه و گروه کنترل اختلاف آماری معنیداری نداشت(0/056=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span style="color:black">P</span></span></span><span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">).</span></span></span><span lang="FA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:95%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="line-height:95%"><span b="" style="font-family:" zar=""><span style="color:black">نتایج این مطالعه نشان داد، درمان مؤثر آبسه حاد اپیکال میتواند باعث افزایش ظرفیت کلی آنتیاکسیدانی و کاهش استرس اکسیداتیو شده و نقش مؤثری در ترمیم صدمات ناشی از فعالیت رادیکالهای آزاد داشته باشد.<span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt"> </span></span></span></span></b></span></span></span></span><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> Antioxidants can prevent oxidative damage caused by increased production of free radicals in oral and dental diseases. In this research, the total antioxidant capacity (TAC) of saliva in patients with acute apical abscess before and after root canal treatment was investigated and compared with a control group.</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Materials and methods:</span></span></span></b><b> </b><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">In this case-control study, salivary antioxidant levels of 20 patients with acute apical abscess were collected before and three weeks after root canal treatment. Also, 20 healthy people (without tooth decay and abscess and without any systemic diseases) were considered as the control group. The ferric reducing ability of plasma (FRAP) was used to measure total antioxidant in the saliva samples and the TAC was evaluated. Then, all data were analyzed in SPSS V16.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Results:</span></span></span></b><b> </b><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">The mean salivary TAC in the case group was 298.8±174.9 </span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="color:black">µmol/L</span></span></span> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">before treatment and 450.9±145.2 </span></span><span style="font-size:10.0pt"><span style="line-height:150%"><span style="color:black">µmol/L</span></span></span> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">after treatment (P=0.009).</span></span> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">However, there was no significant difference in the TAC between the case group after root canal treatment and the control group (P=0.056).</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span arial="" style="font-family:">Conclusion:</span></span></span></b> <span lang="EN" style="font-size:10.0pt"><span style="line-height:150%">This study showed that effective treatment of acute apical abscess can increase the overall antioxidant capacity, reduce oxidative stress, and have an effective role in repairing the damage caused by the activity of free radicals.</span></span><i><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></i></span></span></span></span><br>
ظرفیت کلی آنتیاکسیدان, بزاق, آبسه حاد اپیکال, توانایی پلاسما در احیای یونهای فریک
total antioxidant capacity, saliva, acute apical abscess, ferric reducing ability of plasma
160
165
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-16482-1&slc_lang=fa&sid=1
Sediqe
Ebrahimipour
صدیقه
ابراهیمی پور
sdent22@gmail.com
1003194753284600156017
1003194753284600156017
No
Associate Professor, Department of Endodontics, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
دانشیار، گروه اندودانتیکس، دانشکده دندانپزشکی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
Kowsar
Khosravi
کوثر
خسروی
km.Khosravi77@gmail.com
1003194753284600156018
0009-0005-6120-2137
No
Dental Surgeon, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
دندانپزشک عمومی، دانشکده دندانپزشکی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
Mohadese
Baniasadi
محدثه
بنیاسدی
BaniasadiM991@mums.ac.ir
1003194753284600156019
1003194753284600156019
Yes
Resident in Endodontics, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
دستیار تخصصی درمان ریشه، دانشکده دندانپزشکی، دانشگاه علوم پزشکی مشهد، مشهد، ایران