Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2023
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بررسی متغیرهای شمارش کامل خون (CBC) بدو تولد در نوزادان پرهترم دچار خونریزی مغزی درون بطنی، بستری شده در بیمارستان بوعلی سینا و امام خمینی ساری از سال 95 تا 98
Study of Complete Blood Count Variables at Birth in Preterm Infants with Intraventricular Hemorrhage (IVH) in Bouali Sina and Imam Khomeini Hospital, Sari from 1395 to 1398
هماتولوژی و انکولوژی کودکان
Pediatric Hematology and Oncology
پژوهشي-کامل
Research(Original)
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt">سابقه</span></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt"> و هدف:</span></span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">خونریزی داخل بطنی (</span></span></span><span dir="LTR" lang="EN-GB" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">IVH</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">) به عنوان یک عارضه مهم پرهمچورییتی شناخته میشود. این مطالعه به بررسی متغیرهای شمارش کامل خون (</span></span></span><span dir="LTR" lang="EN-GB" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">CBC</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">) در نوزادان نارس (پرهمچوری) مبتلا به </span></span></span><span dir="LTR" lang="EN-GB" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">IVH</span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">پرداخته است.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt">مواد و روش</span></span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.15pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt">ها:</span></span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">در این مطالعه توصیفی مقطعی نوزادان پرهترم بستری شده در بخش نوزادان و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">NICU</span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">بیمارستان بوعلی سینا و امام خمینی ساری از سال 95 تا 98 بررسی شدند. بیماران مورد مطالعه نوزادان کمتر یا مساوی 34 هفته و کمتر از 1500 گرم بستری در بخش نوزادان یا </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">NICU</span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">هستند. سونوگرافی مغز برای تشخیص </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">IVH </span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">در نوزادان استفاده شد.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt">یافته</span></span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.15pt"></span></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt">ها:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">از 367 نوزاد مورد بررسی، 49/05 درصد پسر و 50/95 درصد دختر بودند. میانگین سن حاملگی2/30</span></span></span><span lang="AR-SA" style="line-height:92%"><span calibri="" style="font-family:"><span style="letter-spacing:-.15pt">±</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">30/96 هفته و میانگین وزن افراد مورد مطالعه</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt"> 505/99 </span></span></span><span lang="FA" style="line-height:92%"><span calibri="" style="font-family:"><span style="letter-spacing:-.15pt">±</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt"> 1461گرم</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">بود. 41 نفر (11/17 درصد) خونریزی داخل بطنی داشتند. نوزادان با سابقه دیابت مادر در گروه با خونریزی داخل بطنی بیشتر بودند (0/042 </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">P</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">=</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">). به طور معنی</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt"></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">داری میانگین هموگلوبین، </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">MCV</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">MCH</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">در گروه با خونریزی بطنی</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">،</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt"> کمتر و میانگین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">CRP</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">و قند خون در این گروه بیشتر بود(0/05</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt"><</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">P</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">). نتایج مدل رگرسیون لجستیک نشان داد که قند خون بالاتر نوزاد، سابقه دیابت مادر، </span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">سابقه </span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">دریافت سورفاکتانت نوزاد و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">MCH</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">MCV</span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">پایینتر در </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">CBC</span></span></span> <span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">نوزاد </span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">بهطور معنی</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt"></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">داری در بروز خونریزی داخل بطنی مؤثرند (0/05</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt"><</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">P</span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">). همچنین هموگلوبین و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">MCH</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">در درجههای دو، سه و چهار خونریزی به طور معنی</span></span></span><span lang="FA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt"></span></span></span><span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">داری کمتر از درجه یک بود.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:92%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="line-height:92%"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.15pt">استنتاج:</span></span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">درپایان با توجه به نتایج به دست آمده از مطالعه حاضر، میتوان تأیید کرد که آنمی هایپوکروم میکروسیتیک در پیشبینی بروز </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:92%"><span style="letter-spacing:-.15pt">IVH</span></span></span> <span lang="AR-SA" style="line-height:92%"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.15pt">مؤثر است.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:140%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:140%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose</span></span></span></span></b><b><span style="font-size:10.0pt"><span style="line-height:140%"><span style="letter-spacing:-.2pt">:</span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:140%"><span style="letter-spacing:-.2pt">Intraventricular hemorrhage (IVH) is known as a major complication<br>
of Prematurity. In this study, we aimed to examine complete blood count (CBC) variables in preterm infants with IVH.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:140%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:140%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Materials and methods:</span></span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:140%"><span style="letter-spacing:-.2pt">In this cross-sectional descriptive study, we studied preterm infants less than or equal to 34 weeks and less than 1500 g admitted to the NICU and neonatal ward of Bu Ali Sina and Imam Khomeini hospitals in Sari from 1395 to 1398. The presence of IVH in brain ultrasonography was recorded in these neonates. </span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:140%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:140%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Results:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:140%"><span style="letter-spacing:-.2pt">Out of 367 neonates, 49.05% were boys and 50.95% were girls. The mean gestational age was 30.96±2.30 weeks and the mean weight of the patients was 1461±504.99 g. 41 patients (11.17%) had intraventricular hemorrhage. Infants with a history of maternal diabetes were more common in the group with intraventricular hemorrhage (P= 0.042). Mean hemoglobin, MCV and MCH were significantly higher in the group with ventricular hemorrhage</span></span></span><span lang="EN-GB" style="font-size:10.0pt"><span style="line-height:140%"> a</span></span><span style="font-size:10.0pt"><span style="line-height:140%"><span style="letter-spacing:-.2pt">nd mean CRP and blood glucose were higher in this group (P<0.05). The results of logistic regression model showed that Higher blood sugar in the newborn, history of diabetes in the mother, history of receiving surfactant in the newborn, and lower MCH and MCV in the newborn baby's CBC were significantly effective in he chance of intraventricular hemorrhage (P<0.05). Also, hemoglobin and MCH were significantly lower in grades 2, 3 and 4 than grade 1of IVH.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:140%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span style="line-height:140%"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Conclusion:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:140%"><span style="letter-spacing:-.2pt">Results of the present study showed that Microcytic hypochromic anemia can be used to predict the occurrence of IVH.</span></span></span></span></span></span></span></span><br>
خونریزی مغزی داخل بطنی, CBC, پرهمچوری
CBC, Intraventricular hemorrhage, Preterm
160
169
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-11917-2&slc_lang=fa&sid=1
Mohammad
Naderisorki
محمد
نادری سورکی
dr.naderisorki@gmail.com
1003194753284600161333
1003194753284600161333
Yes
Assistant Professor, Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
استادیار، مرکز تحقیقات تالاسمی، پژوهشکده هموگلوبینوپاتی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Roya
Farhadi
رویا
فرهادی
dr.royafarhadi@gmail.com
1003194753284600161334
1003194753284600161334
No
Associate Professor, Pediatrics Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran
دانشیار، مرکز تحقیقات بیماریهای عفونی کودکان، دانشگاه علوم پزشکی مازندران، ساری، ایران
Hossein
karami
حسین
کرمی
karami_oncologist@yahoo.com
1003194753284600161335
1003194753284600161335
No
Associate Professor, Ahalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
دانشیار، مرکز تحقیقات تالاسمی، پژوهشکده هموگلوبینوپاتی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Ali
Rezvani Moghaddam
علی
رضوانی مقدم
alidk08@gmail.com
1003194753284600161336
1003194753284600161336
No
Medical Student, Student Research Committe, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
دانشجوی پزشکی، مرکز تحقیقات دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران
Ali Asghar
Nadi Ghara
علی اصغر
نادی قرا
statistic.nadi@gmail.com
1003194753284600161337
1003194753284600161337
No
Assistant Professor, Health Science Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari
استادیار، مرکز تحقیقات علوم بهداشت، پژوهشکده ترک اعتیاد، دانشگاه علوم پزشکی مازندران، ساری، ایران