Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
1
admin
1735-9260
1735-9279
fa
jalali
1402
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2023
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ارتباط سطح سرمی تروپونین I و مرگ و میر داخل بیمارستانی در بیماران مبتلا به کووید-19
Association between Troponin I and In-Hospital Mortality of Covid-19 Patients
اپیدمیولوژی
Epidemiology
گزارش کوتاه
Brief Report
<span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="FA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span> <span lang="FA" style="font-family:"B Zar""><span style="color:black">در بسیاری از مطالعات، سطح بالای تروپونین </span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black">I</span></span><span style="font-family:"B Zar""><span style="color:black"> به عنوان یک شاخص پیش</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">بینی کننده مرگ و میر در <span style="letter-spacing:-.1pt">بیماریهای عفونی معرفی شده است. با توجه به اندازه</span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">های اثر متفاوت در نقاط مختلف، این مطالعه با هدف تعیین ارتباط سطح سرمی تروپونین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">I</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"> ومرگ ومیر داخل بیمارستانی در بیماران مبتلا به کووید-۱۹ بستری در بیمارستانی در شرق ایران انجام شد.</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:#0e101a"><span style="letter-spacing:-.1pt"></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span> <span lang="FA" style="font-family:"B Zar""><span style="color:black">در این مطالعه مورد- شاهدی، 61 نفر بیمار بستری مبتلا به کووید-۱۹ فوت شده (مورد) و61 نفر بیمار زنده و بهبودیافته (شاهد) از نظر سن، جنس و تاریخ بستری همسان شده و مورد بررسی قرار گرفتند. ارتباط بین تروپونین بالا و مرگ با مدل های آماری رگرسیون لجستیک شرطی بررسی شد.</span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span> <span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt">گرچه شانس مرگ در بیماران با سطح بالای تروپونین در ابتدای بستری نسبت به بیماران باتروپونین نرمال حدود</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"> <span style="letter-spacing:-.1pt">38 درصد افزایش یافت؛ اما این ارتباط از نظرآماری معنی</span></span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt">دار نبود (نسبت شانس: 1/38، فاصله اطمینان 95 درصد:5/0</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="color:black"><span style="letter-spacing:-.1pt">-</span></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.1pt"> 0/38).</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:"Times New Roman","serif""><span lang="AR-SA" style="font-family:"B Koodak""><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span> <span lang="FA" style="font-family:"B Zar""><span style="color:black">در این مطالعه یافته</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">ای به نفع تاثیر پیشگویی</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">کننده تروپونین در مرگ بیماران مبتلا به عفونت کووید-۱۹ مشاهده نشد. انجام مطالعات طولی با حجم نمونه</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">های بزرگ</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">تر و بررسی و کنترل مخدوش</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">کننده</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">های بیش</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">تر در مطالعات آینده پیشنهاد می</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"></span></span><span lang="FA" style="font-family:"B Zar""><span style="color:black">شود.</span></span><span lang="AR-SA" style="font-family:"B Zar""><span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span><br>
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<ol>
<li style="text-align:justify"><span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif""><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></span></b> <span style="font-size:10.0pt"><span style="line-height:150%">A wide range of studies have reported the role of troponin I as a predictor of mortality in infectious diseases. According to the various effect measures in different countries, the aim of present study to determine the relationship between serum troponin I level and mortality in hospitalized patients with COVID-19 infection in the east of Iran.</span></span><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="text-autospace:none"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Materials and methods:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">A case-control study was performed. Cases were 61 Covid-19 hospitalized patients (deceased) and 61 recovered patients (controls) who were matched with the corresponding case for age, sex, and admission date were examined. The association between Troponin I and hospital mortality among those patients was investigated using conditional logistic regression models.</span></span><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Results:</span></span></span></b><b> </b><span style="font-size:10.0pt"><span style="line-height:150%">The results of the study revealed that the risk of death in patients with high troponin levels at the beginning of hospitalization was 38% greater than that in individuals with normal troponin levels. However, this relationship was not statistically significant (Odds ratio=1.38, 95% confidence interval: 0.38, 5/0).</span></span><span lang="EN" style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:150%"><span style="vertical-align:top"><span style="font-family:"Times New Roman","serif""><b><span style="font-size:10.0pt"><span style="line-height:150%"><span style="font-family:"Arial","sans-serif"">Conclusion:</span></span></span></b><span style="font-size:10.0pt"><span style="line-height:150%"> The results of our study did not show any findings in favor of the predictive effect of troponin I on the mortality of patients with covid-19 infection. To obtain more accurate results, it is recommended to conduct further longitudinal studies with larger sample sizes and better control of confounding variables.<i><span style="color:black"></span></i></span></span></span></span></span></span><br>
</li>
</ol>
تروپونینI, کووید-19, مرگ و میر
troponin i, covid-19, mortality
343
347
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-16662-1&slc_lang=fa&sid=1
Mahbube
Sheikh
محبوبه
شیخ
drmsh79@gmail.com
1003194753284600162105
1003194753284600162105
No
Assistant Professor, Department of Cardiology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
استادیار، گروه قلب، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران
Nadia
Poudine
نادیا
پودینه
poudinenadia77@gmail.com
1003194753284600162104
0009-0008-7892-6045
Yes
Medical Student, Student Research Committe, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
دانشجوی پزشکی، کمیته تحقیقاتی دانشجویی، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران
Hossein
Pourmasoomi
حسین
پورمعصومی
drhpm@yahoo.com
1003194753284600162106
1003194753284600162106
No
Assistant Professor, Department of Infectious Diseases, Zabol University of Medical Sciences, Zabol, Iran
استادیار، گروه عفونی، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران
Mahdi
Afshari
مهدی
افشاری
mahdiafshari99@gmail.com
1003194753284600162107
1003194753284600162107
No
Professor, Department of Community Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
استاد، گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران