fa اندازه گیری سطح سلنیوم در بیماران مبتلا به زگیل تناسلی در مقایسه با گروه کنترل سالم عفوني infection گزارش کوتاه Brief Report <span style="font-size:16px;"><span style="line-height:2;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span b="" style="font-family:" zar=""><span style="color:black">سلنیوم عنصری کمیاب و ضروری است</span></span><span b="" style="font-family:" zar=""><span style="color:black"> و</span></span><span b="" style="font-family:" zar=""><span style="color:black"> با توجه به نقش سلنیوم در بسیاری از بیماری</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar=""><span style="color:black">های پوستی و</span></span> <span b="" style="font-family:" zar=""><span style="color:black">هم‌چنین نقش آن در سیستم ایمنی، هدف از این مطالعه بررسی سطح سرمی سلنیوم در بیماران مبتلا به زگیل تناسلی و مقایسه آن با افراد سالم می</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span b="" style="font-family:" zar=""><span style="color:black">باشد.</span></span><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">این مطالعه مورد شاهدی بر روی ۴۰ بیمار مبتلا به زگیل تناسلی و ۴۰ فرد سالم صورت گرفت. سطح سرمی سلنیوم به وسیله 2 سی‌سی نمونه خون وریدی توسط کیت آزمایشگاهی </span></span></span><span dir="LTR"><span style="color:black">calbiotech</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black"> اندازه‌گیری شد. مشخصات دموگرافیک و فاکتورهای مرتبط با بیماری ثبت شدند و سپس داده‌ها توسط نرم‌افزار ‌</span></span></span><span dir="LTR"><span style="color:black">SPSS</span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"> نسخه ۲۰ آنالیز شدند.</span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">یافته</span></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">ها:</span></span></span></span> <span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">میانگین سنی افراد در گروه مورد 9/38</span></span></span><span lang="AR-SA"><span style="color:black">&plusmn;</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">30/68 سال و در گروه شاهد 6/90</span></span></span><span lang="AR-SA"><span style="color:black">&plusmn;</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">34/30 سال بود(0/060</span></span></span><span dir="LTR"><span style="color:black">P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">) میانگین سطح سرمی سلنیوم در گروه مورد پایین‌تر از گروه شاهد بود (به ترتیب 35/43</span></span></span><span lang="AR-SA"><span style="color:black">&plusmn;</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">83/92 در مقابل 26/29</span></span></span><span lang="AR-SA"><span style="color:black">&plusmn;</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">93/62 نانوگرم بر میلی‌لیتر) (0/168</span></span></span><span dir="LTR"><span style="color:black">P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">). به‌طور کلی اختلاف آماری معنی‌داری بین سطح سرمی سلنیوم با سن (0/051</span></span></span><span dir="LTR"><span style="color:black">(P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">، جنس (0/062</span></span></span><span dir="LTR"><span style="color:black">P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">)</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">، </span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">تعداد ضایعات (0/750</span></span></span><span dir="LTR"><span style="color:black">P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">) مدت زمان ابتلا به بیماری (0/938</span></span></span><span dir="LTR"><span style="color:black">(P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">، شدت بیماری (0/618</span></span></span><span dir="LTR"><span style="color:black">P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">) و نواحی درگیری پوستی (0/349</span></span></span><span dir="LTR"><span style="color:black">P=</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">) وجود نداشت.</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span><br> <span dir="RTL" lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">در بیماران مبتلا به زگیل تناسلی سطح سرمی سلنیوم پایین</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">تر از افراد سالم بود، که به نوبه خود می</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">تواند نشانگر پایین</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">تر بودن قدرت سیستم ایمنی و بیش</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">تر بودن زمینه</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="FA"><span b="" style="font-family:" zar=""><span style="color:black">های التهابی در بیماران مبتلا به زگیل تناسلی باشد. </span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">مطالعات بیش</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">تری در مورد نقش ایمونومدولاتوری عناصر کمیابی نظیر سلنیوم در عفونت</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">های ویروس پاپیلومای انسانی و انواع زگیل</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span dir="RTL" lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">های پوستی مورد نیاز است</span></span></span></span></span> <span style="line-height:2;"><span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></span></b> <span style="font-size:10.0pt"><span style="color:black">Selenium, a rare and essential element, is crucial in various skin diseases. Given its significance, this study aimed to investigate the serum selenium levels in patients with genital warts and compare them with those of healthy individuals.</span></span><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span arial="" style="font-family:">Materials and methods:</span></span></b><b> </b><span style="font-size:10.0pt"><span style="color:black">This case-control study involved 40 patients with genital warts and 40 healthy individuals. Serum selenium levels were measured using a Calbiotech laboratory kit with two cc of intravenous blood samples. Demographic characteristics and disease-related factors, including disease duration, severity of genital warts, and areas of skin involvement, were recorded. Data were analyzed using SPSS software version 20.</span></span><span style="font-size:10.0pt"><span style="line-height:150%"></span></span></span></span><br> <span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span arial="" style="font-family:">Results:</span></span></b><b> </b><span style="font-size:10.0pt"><span style="color:black">In the case group, the average age was 30.68&plusmn;9.38 years, and in the control group, it was <span style="letter-spacing:-.2pt">34.30&plusmn;6.90 years (P=0.060). The mean serum selenium level in the case group was lower than in the control</span> group (83.92&plusmn;35.43 vs. 93.62&plusmn;26.29 ng/ml, respectively, P=0.168). Notably, there was no statistically significant difference in serum selenium levels with age (P=0.051), gender (P=0.062), number of lesions <span style="letter-spacing:-.1pt">(P=0.750), disease duration (P=0.938), disease severity (P=0.618), or areas of skin involvement (P=0.349).</span></span></span><span lang="EN" style="font-size:10.0pt"><span style="letter-spacing:-.1pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="vertical-align:top"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:10.0pt"><span arial="" style="font-family:">Conclusion:</span></span></b><span style="font-size:10.0pt"> <span style="color:black">Patients with genital warts exhibited lower serum selenium levels than their healthy counterparts, suggesting a potential correlation between weakened immune system strength and increased inflammatory conditions. Future studies are imperative to delve deeper into the immunomodulatory role of trace elements, such as selenium, in human papillomavirus infections and various skin wart types.<i></i></span></span></span></span></span></span><br> &nbsp; زگیل تناسلی, سلنیوم, سیستم ایمنی genital warts, selenium, immune system 134 139 http://jmums.mazums.ac.ir/browse.php?a_code=A-10-1466-153&slc_lang=fa&sid=1 Tahoora Mousavi طهورا موسوی stm.jmums@gmail.com 1003194753284600163460 1003194753284600163460 No Assistant Professor, Molecular and Cell Biology Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran استادیار، مرکز تحقیقات بیولوژی سلولی مولکولی، پژوهشکده هموگلوبینوپاتی، دانشگاه علوم پزشکی مازندران، ساری، ایران Naser Emadi ناصر عمادی nemadi@mazums.ac.ir 1003194753284600163461 1003194753284600163461 No Associated Professor, Department of Dermatology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran دانشیار، گروه پوست، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران Sadaf Barimani صدف بریمانی sbarimani@mazums.ac.ir 1003194753284600163462 1003194753284600163462 No Medical student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran دانشجوی پزشکی، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران Armaghan Kazeminejad ارمغان کاظمی نژاد armaghanjgh@yahoo.com 1003194753284600163463 1003194753284600163463 Yes Assistant Professor, Department of Dermatology, Bouali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran استادیار، گروه پوست، بیمارستان بوعلی سینا، دانشگاه علوم پزشکی مازندران، ساری، ایران