fa بررسی بیان miR-210 در بیماران مبتلا به سرطان پستان هماتولوژی و آنکولوژی Hematology and Oncology گزارش کوتاه Brief Report <span style="font-size:16px;"><span style="line-height:2;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="FA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">سرطان پستان یکی از سرطان<span style="color:black">‌</span>های شایع در میان زنان می<span style="color:black">‌</span>باشد. بیان غیرمعمول </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">MicroRNA</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> ها با سرطان</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""> در ارتباط می<span style="color:black">‌</span>باشد. این مطالعه با هدف ارزیابی بیان </span></span><span dir="LTR">miRNA-210</span><span lang="AR-SA"><span b="" style="font-family:" zar=""> در سرم بیماران مبتلا به سرطان پستان انجام پذیرفت.</span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:#0e101a"></span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">مواد و روش</span></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA"><span b="" style="font-family:" zar="">جامعه مورد مطالعه شامل 49 بیمار مبتلا به سرطان پستان و 55 فرد سالم بوده و</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""> نمونه‌ها با استفاده از </span></span><span dir="LTR">Real Time PCR</span><span lang="AR-SA"><span b="" style="font-family:" zar=""> مورد ارزیابی قرار گرفت.</span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"></span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">یافته</span></span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span></span></span><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">ها:</span></span></span></span> <span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">آنالیز داده</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">های این مطالعه نشان داد که سطح بیان </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">miR-210</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> در خون بیماران مبتلا به سرطان پستان به صورت معنی</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="color:black">‌</span></span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">داری افزایش یافته است. هم<span style="color:black">‌</span>چنین یک ارتباط منفی بین سن بیماران مبتلا به سرطان پستان و بیان </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">miR-210</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> (0/031 =</span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">P</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">، 0/309&nbsp;</span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">-</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> = </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">r</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">) و یک ارتباط مثبت بین افزایش بیان </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">mir-210</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> و میزان مارکر </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">Ki-67</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> وجود دارد (0/004 =</span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">P</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">، 0/412</span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">-</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt"> = </span></span></span><span dir="LTR"><span style="letter-spacing:-.1pt">r</span></span><span lang="AR-SA"><span b="" style="font-family:" zar=""><span style="letter-spacing:-.1pt">).</span></span></span><span lang="FA"><span b="" style="font-family:" zar=""><span style="color:black"><span style="letter-spacing:-.1pt"></span></span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA"><span b="" koodak="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.2pt">استنتاج:</span></span></span></span> <span lang="AR-SA"><span b="" style="font-family:" zar="">ارزیابی </span></span><span dir="LTR">miR-210</span><span lang="AR-SA"><span b="" style="font-family:" zar="">، می<span style="color:black"><span style="letter-spacing:-.1pt">‌</span></span>تواند به عنوان یک مارکر احتمالی تشخیصی در سرطان پستان استفاده شود.<span style="color:black"><span style="letter-spacing:-.2pt"></span></span></span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:16px;"><span style="line-height:2;"><span new="" roman="" style="font-family:" times=""><b><span arial="" style="font-family:"><span style="letter-spacing:-.2pt">Background and purpose:</span></span></b> <span style="letter-spacing:-.2pt">Breast cancer is one of the most common cancers among women. Abnormal expression of microRNAs is associated with cancer. Therefore, this study aimed to evaluate the expression of miRNA-210 in the serum of breast cancer patients.</span><span style="line-height:150%"></span></span><br> <span new="" roman="" style="font-family:" times=""><b><span arial="" style="font-family:">Materials and methods:</span></b><b> </b><span style="letter-spacing:-.2pt">The studied population included 49 breast cancer patients and 55 healthy individuals, and the samples were evaluated using Real Time PCR.</span><span style="line-height:150%"></span></span><br> <span new="" roman="" style="font-family:" times=""><b><span arial="" style="font-family:">Results:</span></b><b> </b><span style="letter-spacing:-.2pt">The data analysis of this study revealed that the expression level of miR-210 in the blood of breast cancer patients is significantly higher compared to the blood of healthy people. Also, there is a negative correlation between the age of breast cancer patients and the expression of miR-210 (r=-0.309, P=0.031) and a significant positive correlation between the increase in the expression of mir-210 and the expression of the Ki-67 marker (r=0.412, P = 0.004).</span><span lang="EN"><span style="line-height:150%"></span></span></span></span></span><br> &nbsp; سرطان پستان, MicroRNA, مارکر Evaluation of miR-210 can be used as a diagnostic marker in breast cancer 118 125 http://jmums.mazums.ac.ir/browse.php?a_code=A-10-412-11&slc_lang=fa&sid=1 Omolbanin Amjadi ام البنین امجدی 1003194753284600162958 1003194753284600162958 No MSc in Cell and Molecular Biology, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran کارشناس ارشد سلولی و مولکولی، مرکز تحقیقات سرطان گوارش، پژوهشکده بیماری های غیر واگیر، دانشگاه علوم پزشکی مازندران، ساری، ایران Fatemeh Samadi فاطمه صمدی 1003194753284600162959 1003194753284600162959 No Medical Student, Mazandaran University of Medical Sciences, Sari, Iran دانشجوی پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران Reza Alizadeh-Navaei رضا علیزاده نوایی reza.nava@yahoo.com 1003194753284600162960 1003194753284600162960 No Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran دانشیار، مرکز تحقیقات سرطان گوارش، پژوهشکده بیماری های غیر واگیر، دانشگاه علوم پزشکی مازندران، ساری، ایران Reza Valadan رضا ولدان 1003194753284600162961 1003194753284600162961 No Assistant Professor, Cellular and Molecular Research Center, Mazandaran University of Medical Sciences, Sari, Iran استادیار، مرکز تحقیقات سلولی و مولکولی، دانشگاه علوم پزشکی مازندران، ساری، ایران Ehsan Zaboli احسان زابلی 1003194753284600162962 1003194753284600162962 No Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran دانشیار، مرکز تحقیقات سرطان گوارش، پژوهشکده بیماری های غیر واگیر، دانشگاه علوم پزشکی مازندران، ساری، ایران Najmeh Ahangar نجمه آهنگر 1003194753284600162963 1003194753284600162963 No BSc in Laboratory Science, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran لیسانس علوم آزمایشگاهی، مرکز تحقیقات سرطان گوارش، پژوهشکده بیماری های غیر واگیر، دانشگاه علوم پزشکی مازندران، ساری، ایران Elahe Mahmoodi الهه محمودی 1003194753284600162964 1003194753284600162964 No MSc in Statistics, Mazandaran University of Medical Sciences, Sari, Iran کارشناس ارشد آمار، دانشگاه علوم پزشکی مازندران، ساری، ایران Akbar Hedayatizadeh-Omran اکبر هدایتی زاده عمران akbar_hedayati@yahoo.com 1003194753284600162965 1003194753284600162965 Yes Associate Professor, Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran دانشیار، مرکز تحقیقات سرطان گوارش، پژوهشکده بیماری های غیر واگیر، دانشگاه علوم پزشکی مازندران، ساری، ایران