fa بررسی علل بروز تب در بیماران نوتروپنیک مبتلا به سرطان در بیمارستان های آموزشی دانشگاه علوم پزشکی آبادان هماتولوژی و آنکولوژی Hematology and Oncology گزارش کوتاه Brief Report <span style="font-size:16px;"><span style="line-height:2;"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span lang="FA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:black"><span style="letter-spacing:-.1pt">سابقه</span></span></span></span><span lang="AR-SA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:black"><span style="letter-spacing:-.1pt"> و هدف:</span></span></span></span> <span lang="FA" style="font-family:&quot;B Zar&quot;">تب و نوتروپنی از جمله عوارض شایع و علل مهم بستری بیماران مبتلا به سرطان می</span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA" style="font-family:&quot;B Zar&quot;">باشد. این عارضه می</span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA" style="font-family:&quot;B Zar&quot;">تواند میزان مرگ و میر بیماران را افزایش دهد. این مطالعه با هدف بررسی علل بروز تب در بیماران نوتروپنیک مبتلا به سرطان در بیمارستان</span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA" style="font-family:&quot;B Zar&quot;">های آموزشی دانشگاه علوم پزشکی آبادان در سال 1401، انجام پذیرفت.</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;"></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span lang="FA"><span style="font-family:&quot;B Koodak&quot;">مواد و روش</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;"><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="FA"><span style="font-family:&quot;B Koodak&quot;">ها:</span></span> <span lang="FA"><span style="font-family:&quot;B Zar&quot;">این مطالعه از نوع توصیفی- تحلیلی و گذشته‌نگر، بود. در این مطالعه 206 بیمار مبتلا به سرطان و تب و نوتروپنی مراجعه کننده به بیمارستان</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">های آموزشی دانشگاه علوم پزشکی آبادان در سال ۱۴۰۱، وارد مطالعه شدند. اطلاعات مربوط به بیماران با استفاده از پرونده بیماران و سیستم </span></span><span dir="LTR">HIS</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;"> با استفاده از چک لیست جمع‌آوری و مورد تجزیه و تحلیل آماری قرار گرفت.</span></span><span lang="FA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:#0e101a"></span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span lang="AR-SA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:black">یافته</span></span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;"><span style="color:black"><span style="letter-spacing:-.2pt">‌</span></span></span></span><span lang="AR-SA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:black">ها:</span></span></span> <span lang="FA"><span style="font-family:&quot;B Zar&quot;">میانگین درجه حرارت در بیماران با وجود شیمی درمانی به شکل معنی</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">داری از بیماران بدون شیمی درمانی بیش</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">تر بوده است (0/001</span></span><span dir="LTR"><</span> <span dir="LTR">P</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">). میانگین درجه حرارت بیماران با مدت تب بیش</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">تر از 5 روز به شکل معنی</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">داری بیش</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">تر از بیماران با مدت تب کم</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">تر از 5 روز بود (0/024= </span></span><span dir="LTR">P</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">). بین درجه حرارت بدن و </span></span><span dir="LTR">WBC</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;"> روز اول و روز آخر ارتباط معنی دار و معکوسی برقرار است (0/001=</span></span><span dir="LTR">P</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;"> و 0/01=</span></span><span dir="LTR">P</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">). هم</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">چنین بین درجه حرارت بدن و نوتروفیل روز اول و روز آخر ارتباط معنی</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">دار و معکوسی برقرار بود (هر دو0/04= </span></span><span dir="LTR">P</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">). بین اسپلنکتومی با درجه حرارت در بیماران با تب و نوتروپنیک ارتباط معنی</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">داری وجود داشت (0/001</span></span><span dir="LTR"><</span> <span dir="LTR">P</span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">).</span></span><span lang="AR-SA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:black"></span></span></span></span></span></span><br> <span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span lang="AR-SA"><span style="font-family:&quot;B Koodak&quot;"><span style="color:black">استنتاج:</span></span></span> <span lang="FA"><span style="font-family:&quot;B Zar&quot;">در مجموع مدت تب، انجام شیمی درمانی و انجام اسپلنکتومی با تب با درجه حرارت بالا ارتباط معنی</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">داری داشت. هم</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">چنین، میزان نوتروفیل و گلبول سفید بدن در روز اول و آخر با درجه حرارت بدن مرتبط بودند، به</span></span><span lang="AR-SA" style="font-family:&quot;B Zar&quot;"><span style="letter-spacing:-.2pt">‌</span></span><span lang="FA"><span style="font-family:&quot;B Zar&quot;">طوری که این ارتباط معکوس بوده و کاهش نوتروفیل و گلبول سفید با افزایش درجه حرارت همراه است.</span></span></span></span></span></span></span><br> &nbsp; <span style="font-size:16px;"><span style="line-height:2;"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"><span style="letter-spacing:-.1pt">Background and purpose:</span></span></b> Fever and neutropenia are common complications and significant causes of hospitalization in cancer patients. These conditions&nbsp;can increase the mortality rates among patients. The aim of this study was to investigate the etiologies of fever in neutropenic cancer patients&nbsp;admitted to the teaching hospitals affiliated with Abadan University of Medical Sciences.</span><br> <span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Materials and methods:</span></b> This study was a descriptive-analytical, retrospective investigation. A total of 206 cancer patients presenting with fever and neutropenia, who were referred to the teaching hospitals affiliated with Abadan University of Medical Sciences in 2022, were included in the study. Patient information was collected through medical records and data retrieved from the Hospital Information System (HIS) using a structured checklist, and subsequently analyzed statistically.</span><br> <span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;"><span style="letter-spacing:-.2pt">Results:</span></span></b> <span style="letter-spacing:-.2pt">The mean body temperature in patients&nbsp;who had received chemotherapy was significantly higher than that in patients who had not undergone chemotherapy (P<0.001). The mean temperature of patients with a fever duration of more than five days was also significantly higher than that of patients with a fever duration of less than five days (P= 0.024). A significant and inverse relationship was observed between body temperature and white blood cell (WBC) count on&nbsp;both&nbsp;the first and last day (P= 0.001 and P= 0.01, respectively). In addition, there was a significant and inverse relationship between body temperature and neutrophil count on both the first and last day (both P = 0.04). A significant&nbsp;relationship was also found between splenectomy and body temperature in patients with fever and neutropenia (P< 0.001).</span></span><br> <span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-family:&quot;Arial&quot;,&quot;sans-serif&quot;">Conclusion</span></b><b>:</b> Overall, fever duration, chemotherapy, and splenectomy were significantly associated with elevated body temperature. In addition, the findings indicated that neutrophil and white blood cell counts on both the first and last day were&nbsp;significantly associated with body temperature, such that this relationship was inverse, a decrease in neutrophils and white blood cells was associated with an increase in temperature.</span></span></span><br> &nbsp; نوتروپنی, تب, سرطان, شیمی درمانی, اسپلنکتومی neutropenia, fever, cancer, chemotherapy, splenectomy 176 181 http://jmums.mazums.ac.ir/browse.php?a_code=A-10-15935-2&slc_lang=fa&sid=1 Sahar Khattaviann سحر خطاویان 1003194753284600177779 1003194753284600177779 No General Practitioner, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran دکتری پزشکی عمومی، دانشکده پزشکی، دانشگاه علوم پزشکی آبادان، آبادان، ایران Sajedeh Mousaviasl ساجده موسوی اصل 1003194753284600177780 1003194753284600177780 No Nursing Instructor, Department of Nursing, Faculty of Nursing, Abadan University of Medical Sciences, Abadan, Iran مربی ، گروه پرستاری، دانشکده پرستاری، دانشگاه علوم پزشکی آبادان، آبادان ، ایران Esmat Radmanesh عصمت رادمنش 1003194753284600177781 1003194753284600177781 No Associate Professor, Department of Physiology, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran دانشیار، گروه فیزیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی آبادان، آبادان، ایران Bagher Pahlavanzade باقر پهلوان زاده 1003194753284600177782 1003194753284600177782 No Assistant Professor, Department of Biostatistics, Faculty of Health, Abadan University of Medical Sciences, Abadan, Iran استادیار، گروه آمار، دانشکده بهداشت، دانشگاه علوم پزشکی آبادان، آبادان، ایران Sara Mobarak سارا مبارک 1003194753284600177778 1003194753284600177778 Yes Associate Professor, Department of Infectious Diseases, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran دانشیار، گروه بیماری های عفونی، دانشکده پزشکی، دانشگاه علوم پزشکی آبادان، آبادان، ایران