Journal of Mazandaran University of Medical Sciences
مجله دانشگاه علوم پزشکی مازندران
J Mazandaran Univ Med Sci
Medical Sciences
http://jmums.mazums.ac.ir
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2014
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ارزیابی اثر ضد باروری عصاره آبی سداب در موش ماده
Antifertility Effect of Ruta graveolens Aqueous Extract in Female Mice
مامائی
Midwifery
پژوهشي-کامل
Research(Original)
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<p style="text-align: justify line-height: 200% direction: rtl unicode-bidi: embed" dir="rtl" class="MsoNormal"><span lang="AR-SA" style="font-size: 16pt line-height: 200% font-family: "B Koodak"">چکیده</span></p>
<p style="text-align: justify text-indent: 17pt line-height: 200% direction: rtl unicode-bidi: embed" dir="rtl" class="MsoNormal"><span lang="FA" style="line-height: 200% font-family: "B Koodak"">سابقه</span><span lang="AR-SA" style="line-height: 200% font-family: "B Koodak""> و
هدف:</span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""> وتاگراوئولنس </span><span dir="ltr"></span><span style="font-size: 10pt line-height: 200%" dir="ltr"><span dir="ltr"></span>(RG)</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> به طور معمول تحت عنوان سداب، از زمان قدیم به عنوان یک گیاه
دارویی شناخته شده است. فعالیت آنتی اکسیدانی، ضد التهاب، ضد تومور و ضد آندروژن از
جمله خواص دارویی </span><span style="font-size: 10pt line-height: 200%" dir="ltr">RG</span><span dir="rtl"></span><span style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> <span lang="AR-SA">است. این مطالعه به منظور ارزیابی اثرات ضد
باروری عصاره آبی سداب و میزان رشد داخل آزمایشگاهی جنین ها در موش ماده صورت
پذیرفته است.</span></span><span lang="FA" style="line-height: 200% font-family: "B Zar""></span></p>
<p style="text-align: justify text-indent: 17pt line-height: 200% direction: rtl unicode-bidi: embed" dir="rtl" class="MsoNormal"><span lang="AR-SA" style="line-height: 200% font-family: "B Koodak"">مواد و روش</span><span lang="FA" style="line-height: 200% font-family: "B Zar" letter-spacing: -0.2pt"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Koodak"">ها:</span><span lang="AR-SA" style="line-height: 200%"> </span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar"">در
مطالعه تجربی حاضر، 30 موش ماده استفاده شد. حیوانات به 2 گروه کنترل و </span><span style="font-size: 10pt line-height: 200%" dir="ltr">RG</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> تقسیم شدند. گروههای کنترل 2/0 میلی لیتر نرمال سالین و گروههای
</span><span style="font-size: 10pt line-height: 200%" dir="ltr">RG</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> عصاره آبی </span><span style="font-size: 10pt line-height: 200%" dir="ltr">RG</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> را با دوز</span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""> </span><span style="font-size: 10pt line-height: 200%" dir="ltr">mg/kg</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> 300 در هر روز به صورت خوراکی به
مدت 14 روز دریافت کردند. اووسیتهای بالغ به محیط کشت </span><span style="font-size: 10pt line-height: 200%" dir="ltr">HTF</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> حاوی</span><span style="font-size: 10pt line-height: 200%" dir="ltr">mg/ml) BSA </span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span><span> </span>4</span><span dir="ltr"></span><span style="font-size: 10pt line-height: 200%" dir="ltr"><span dir="ltr"></span>(</span><span dir="rtl"></span><span style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> <span lang="AR-SA">انتقال داده شدند. درصد اووسیتهای لقاح یافته،
جنینهای دو سلولی، بلاستوسیستها و جنینهای هچ شده پارامترهای مورد ارزیابی در
این مطالعه بودند. </span></span><span lang="FA" style="line-height: 200% font-family: "B Zar""></span></p>
<p style="text-align: justify text-indent: 17pt line-height: 200% direction: rtl unicode-bidi: embed" dir="rtl" class="MsoNormal"><span lang="AR-SA" style="line-height: 200% font-family: "B Koodak"">یافته</span><span lang="FA" style="line-height: 200% font-family: "B Zar" letter-spacing: -0.2pt"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Koodak"">ها:</span><span lang="AR-SA" style="font-size: 14pt line-height: 200% font-family: "B Lotus""> </span><span style="font-size: 10pt line-height: 200%" dir="ltr">RG</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> در مقایسه با گروه کنترل باعث کاهش معنیدار (05/0</span><span style="font-size: 10pt line-height: 200%" dir="ltr">p<</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span>) در رشد جنینها در مراحل مختلف شد. این در حالی است که با توقف
مصرف عصاره، تفاوت معنیداری بین گروه کنترل و آزمایشی مشاهده نشد.</span><span lang="FA" style="line-height: 200% font-family: "B Zar""></span></p>
<p style="text-align: justify text-indent: 17pt line-height: 200% direction: rtl unicode-bidi: embed" dir="rtl" class="MsoNormal"><span lang="AR-SA" style="line-height: 200% font-family: "B Koodak"">استنتاج:</span><span lang="AR-SA" style="line-height: 200%"> </span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar"">نتایج این
مطالعه نشان داد که مصرف عصاره آبی </span><span style="font-size: 10pt line-height: 200%" dir="ltr">RG</span><span dir="rtl"></span><span lang="AR-SA" style="line-height: 200% font-family: "B Zar""><span dir="rtl"></span> با کاهش رشد جنینها، توان
باروری را در موشهای ماده کاهش میدهد. مضافاً اینکه اثرات منفی سداب بر باروری
با قطع مصرف برگشتپذیر میباشد.</span><span lang="FA" style="font-family: "B Zar""></span></p>
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Abstract
Background and purpose: Ruta Graveolens (RG) commonly called sudab, has been known as a medicinal plant since ancient times. Anti-oxidant, anti-inflammatory, anti-tumor, anti-androgenic, and anti-fertility activities are amongst the medicinal properties of RG. The present study investigated the antifertility effects of RG and in-vitro embryo development in female mice.
Materials and methods: The study was performed in 30 female mice that were divided into two groups as control and RG. The control group received normal saline 0.2 ml and the RG group received 300 mg/kg aqueous extract of RG per day, orally for 14 days. Matured oocytes were transported to HTF+BSA (4mg/ml). Then fertilized oocytes, two cell, blastocyst and hatching embryos were evaluated.
Results: In case group RG reduced embryo growth (P<0.05) at different stages. However, by disrupting RG administration no significant differences were observed between control and test animals.
Conclusion: The results showed that the aqueous extract of RG decreased the embryo growth and fertilizing ability in female mice. Moreover, the negative impact of RG on fertilizing potential is recurrentable after disruption of exposure.
ضد باروری, روتاگراوئولنس, موش
Anti-fertility, Rutagraveolens, Mice
133
142
http://jmums.mazums.ac.ir/browse.php?a_code=A-10-1269-11&slc_lang=fa&sid=1
Aref
Hoshyari
عارف
هوشیاری
100319475328460038432
100319475328460038432
No
DVSc Student, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
دانشجوی دکتری تخصصی علوم تشریح، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران
Golamreza
Najafi
غلامرضا
نجفی
g.najafi2006@yahoo.com
100319475328460038433
100319475328460038433
Yes
Assistant Professor, Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
استادیار، گروه آناتومی- بافت شناسی و جنین شناسی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران
Rajabali
Sadrkhanlo
رجبعلی
صدرخانلو
100319475328460038434
100319475328460038434
No
Professor, Department of Histology and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
استاد، گروه بافت شناسی و جنین شناسی، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران
Leila
Roshangar
لیلا
روشنگر
100319475328460038435
100319475328460038435
No
Professor, Department of Histology and Embryology, Faculty of Medicine, Tabriz University, Tabriz, Iran
استاد، گروه بافت شناسی و جنین شناسی، دانشکده پزشکی، دانشگاه تبریز، تبریز، ایران