2024-03-28T17:36:51+03:30 http://jmums.mazums.ac.ir/browse.php?mag_id=73&slc_lang=fa&sid=1
73-1319 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Study of HER1, HER2 Over Expression in Locally Advanced Gastric Cancer and its Correlation with Overall Survival Ghasem Janbabaee Farshad Naghshvar farshad.naghshvar@yahoo.com Tooraj Farazmandfar Mostafa Salehi Masoomeh Rashidi Background and purpose: Mortality rate from gastric cancer is growing in the world. Nowadays, in many cancers, between cancer development and changes in EGF receptor expression levels there is a very precise relationship. Perhaps one of the best known of these changes in gastric cancer is over expression of Her1 & 2 receptors. This study investigated the expression rate of these two receptors in gastric locally advanced adenocarcinoma, and its correlation with survival of patients. Materials and methods: The samples include 130 paraffin blocks of patients with gastric cancer in Imam Khomeini Hospital in Sari 1383-88. 4 micron sections of tissue blocks were prepared and placed on slides. Then slides were deparaffinized with xylene and dehydrated using alcohol. The endogenous peroxidase activity was inhibited. Her2 Antibody is located on them. Finally, they were stained with hematoxylin. Results: Her1 marker only in 23 samples (17.6 %) and Her2 marker only in 20 samples (15.4 %) were positive. Accompanying these two markers in 9 patients (6.9 %) was also seen simultaneously. The survey marker Her2 based on sex revealed in 91 male patients, only in 11 cases (11.6 %) and in 39 women only 9 cases (23 %) were positive Conclusion: Expression levels of Her1 marker increased with increasing disease stage. These findings may indicate the diagnostic value of this marker in patients with gastric adenocarcinoma. Probably, the rate of HER1 and HER2 receptors expression is associated with invasion and survival of patients. Gastric CA HER1 marker HER2 marker 2012 8 01 2 7 http://jmums.mazums.ac.ir/article-1-1319-en.pdf
73-1298 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Investigating the Cytotoxic Effects of Penicillium Citrinum on Cancer Cell Lines (HepG2), (A549), (SKOV3), (MCF7) and Normal Cell Lines (LLCPK1), (CHO) by MTT Assay mohammad shokrzadeh hamid badali : badalii@yahoo.com Jamshid Yazdani Zeinab Amiri Mahmood Omidi Background and purpose: Penicilliums have high diversity among fungi species and some of them are found to be very useful. Some studies have evaluated their antimicrobial and cytotoxic effects. Penicillium citrinum is a genus of the penicilliums that produces mycotoxin citrinin. Therefore, it is worthy to assess its cytotoxic effect. Materials and methods: The DNA of the fungus obtained from the soil samples from the campus of Mazandaran University of Medical sciences was extracted. Then DNA sequencing was done and the ethanolic extract including metabolites was taken out. The effect of different concentrations of test solution were evaluated on cancer cell lines of human liver (HepG2), lung (A549), ovary (SKOV3), and breast (MCF7) and also on kidney (LLCPK1) and ovary of Hamster (CHO) normal cell lines using MTT method. Cisplatin was considered as positive control. The data was analyzed using Prism Ver.3, ANOVA and t-test. Results: The findings revealed significant differences between the levels of IC50 of fungus metabolites and cisplatin in all cell lines (P< 0.005). Also, the level of IC50 of fungus metabolites on normal cell lines was significantly different from that of the cancer cell lines (P< 0.05). Conclusion: This study showed that ethanolic extract of P. citrinum metabolites did not have a considerable toxicity effect on cancer and normal cell lines. However, it increaesd the inhibitory effect of cancer cell proliferation. Penicillium citrinum cancer and normal cell lines IC50 MTT assay 2012 8 01 9 17 http://jmums.mazums.ac.ir/article-1-1298-en.pdf
73-1567 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Effect of Self-Management Program on Self-Efficacy in Hypertensive Patients Omolhoda Kaveh Savadkooh Masoomeh Zakerimoghadam zakerimo@tums.ac.ir E-mail: Shahrzad Gheyasvandian Anooshirvan Kazemnejad Background and purpose: Hypertension is a common chronic and relapsing disease caused by extensive and long-term changes in behavior related to lifestyle and is considered as a challenging issue throughout the world. The aim of this study was to assess the effect of self-management program on self- efficacy among hypertensive patients. Materials and methods: This quasi-experimental study was performed in 150 patients with mild-to-moderate primary hypertension attending health centers affiliated to Tehran University of Medical Sciences. The subjects were randomly assigned into two groups of experimental (n= 75) and control (n= 75). The intervention consisted of a one-day workshop for four hours and the scenario project. The subjects were then followed up through phone call: within two months. The data was analyzed using SPSS-16 and descriptive and analytical statistics. Results: The results showed significant differences among experimental and control group regarding the rate of self-efficacy after the intervention (P=0.000). In fact self-management program increased the patients' level of self-efficacy. Conclusion: Self-management program which results in higher level of self-efficacy could motivate the patients to change their behaviors, adherence to diet, medication, exercise and physical activity. Blood pressure thereby would be controlled. Self-management program self-efficacy primary hypertension 2012 8 01 19 28 http://jmums.mazums.ac.ir/article-1-1567-en.pdf
73-1303 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Relationship between Insulin Receptor (INSR rs 1799817) and Colorectal Cancer (CRC) Khatoon Karimi Maral Arkani Akram Safaei akramsafaei.134@gmail.com Mohsen vahedi Seyed Reza Mohebi Seyed Reza Fatemi mohammad Vafaei Mohammad Reza Zali Background and purpose: Insulin regulates cell growth and apoptosis by binding to its receptor (INSR). Many studies show that variation in insulin pathway play a plausible role in the development of colorectal cancer (CRC). The goal of this study was to evaluate the incidence of insulin receptor (INSR rs1799817) in people attending Taleghani Hospital and to investigate the role of this polymorphism in increased risk to CRC. Materials and methods: In this case-control study genotyping of the insulin receptor (INSR rs1799817) were determined in a series of 110 colorectal cancer patients and 110 controls using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP). To investigate the relationship between genotypes and risk of CRC SPSS (V16) was used. Results: The results showed that polymorphism INSR rs 1799817 was not a predisposing factor for increased risk of CRC (P= 0.49). There was no significant difference in the incidence of mutant allele between the patients and controls (OR= 1.12 95% CI= 0.73-1.69). Conclusion: These findings suggest that polymorphism insulin receptor rs 1799817 is not associated with increased risk of CRC. Colorectal cancer Insulin receptor gene PCR–RFLP 2012 8 01 30 35 http://jmums.mazums.ac.ir/article-1-1303-en.pdf
73-1299 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Ability to Correct Interpretation of Chest X-ray by Emergency Medicine Residents in Three Public Hospitals Hamid Kariman Amir Khalili Khaliliamir@yahoo.com Shahram Alamdari Majid Shojaee Afshin Amini Mostafa Alavi Moghadam Background and purpose: Chest X Ray (CXR) is one of the most common radiography uses in the emergency department. Availability of radiologists varies in different emergency centers, therefore, the ability to accurately interpret chest X-rays is highly crucial for residents in emergency medicine programs. The present article evaluates this ability in residents of emergency medicine. Materials and methods: In this cross-sectional study 11 CXRs with specified interpretation were selected from radiologic text books and given to residents of emergency medicine of three educational hospitals for interpretation. SPSS 18 was used to analyze the responses. Results: A total of 114 residents were studied. The mean score achieved by residents in emergency medicine programs was 7.2 ± 2.5 (65.4% of the questions were answered correctly). The average score of students undertaking emergency medicine in Imam Khomeini, Rasool Akram and Imam Hossein Hospitals were 6.4 ± 1.7, 8.5 ± 3.2, and 6.8 ± 1.9, respectively (P= 0.001). No significant correlation was found between level of residency and the mean score achieved by the study population (P> 0.05). However, the average score among students who passed radiology rotation was significantly higher. Conclusion: Enhancing the quality and quantity of radiologic courses are necessary to increase the ability of residents in emergency medicine in CXR interpretation. Chest X Ray emergency medicine interpretation of radiography 2012 8 01 37 43 http://jmums.mazums.ac.ir/article-1-1299-en.pdf
73-1295 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Seroepidemiology of Crimean-Congo hemorrhagic fever in High Risk Professions in Yasuj Abolghasem Hadinia Owrangeilami@yahoo.com Owrang Ilami Ali Mousavizadeh Mahdi Akbartabar Tori Seyed Abdolmajid Khosravani Background and purpose: Crimean-Congo hemorrhagic fever is a zoonotic disease that has been reported from different parts of Iran. The aim of this study was to investigate the Seroepidemiology of Crimean-Congo hemorrhagic fever in high risk professions in Yasuj, Iran. Materials and methods: The present study included 108 subjects at risk 34 butchers, 20 slaughters, 14 slaughter-house workers, 20 waiters, and 20 housewives were randomly selected. After completing the demographic characteristics and history of febrile diseases, blood samples were obtained and specific IgG antibodies against Crimean-Congo hemorrhagic fever virus were tested. The collected data were analyzed with descriptive statistics and percentages and chi-square tests. Results: Of the 108 subjects, 5 (4.6 percent) with positive serology were among restaurant the workers 2 (10 percent) and slaughterers 3 (15 percent), respectively, which was statistically significant. There were no positive serologies in the other groups. Conclusion: The present study showed that the Seroepidemiology of Crimean-Congo hemorrhagic fever in high risk professions is not highly prevalent in Yasuj, Iran. However, the need for further surveillance and prevention programs is still recommended. Crimean-Congo Fever seroepidemiology high risk 2012 8 01 45 50 http://jmums.mazums.ac.ir/article-1-1295-en.pdf
73-1338 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 The Effects of Foot Reflexology Massage on Pain and Fatigue of Patients After Coronary Artery Bypass Graft Masoumeh Bagheri-Nesami Nahid Zargar zar200777@yahoo.com E-mail: Afshin Gholipour-Baradari Alireza Khalilian Background and purpose: Pain and fatigue are among the complications after coronary artery bypass graft surgery (CABG). Non- pharmacological methods are more favorable than pharmacological agents. This study assessed the effects of foot reflexology massage on pain and fatigue in patients after CABG. Materials and methods: A randomized controlled clinical trial was conducted in 80 patients hospitalized in Mazandaran Heart Center, 2011. The samples were allocated based on their accessibility. They were age and gender matched and then divided randomly into two groups of case and control. The case group received reflexology massage on left foot for 20 minutes from the second day after surgery for four consecutive days. In control group, the left foot of the patients was moisturized for one minute without applying any pressure. The intensity of pain and fatigue were recorded before and after the intervention using visual analogue scale. Descriptive and inferential statistics were used to analyze the data. Results: Results showed significant differences in pain and fatigue levels after the intervention among both groups (P= 0.0001). Conclusion: According to this study, foot reflexology massage, is a useful nursing intervention to relieve fatigue and pain in CABG patients. Since this low-cost method is easy to apply we recommend it to ease the pain and fatigue in patients after CABG. Foot reflexology massage pain fatigue coronary artery bypass graft (CABG) 2012 8 01 52 62 http://jmums.mazums.ac.ir/article-1-1338-en.pdf
73-1304 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Zoning of water quality on Haraz river bases on National Sanitation Foundation Water Quality Index Kamran Nasirahmadi Zabihollah Yousefi Ahmad Tarassoli Background and purpose: In order to identify the impact of aquaculture effluents systems, industrial, agricultural and residential centers, between the output of water from Lar dam up the water input to the Caspian Sea in 7 different stations, river water quality parameters from October 1388 to September 1389 was studied and evaluated with water quality index. Materials and methods: This experimental study was conducted on Haraz river. In order to identify the impact of aquaculture effluents, industrial, agricultural and residential centers, between the output of water from Lar dam up the water input to the Caspian Sea in 7 different stations, river water quality parameters from October 1388 to September 1389 studied and evaluated. Sampling, sample preparation and analysis, according to standard methods (1998) were done. Results: Results of statistical analysis data indicate that the parameters of BOD, TS, EC, turbidity, nitrate, phosphate, and fecal coliform in the effluent entering the river to the plains and the confluence with agricultural and residential centers based on indicators of water quality NSFWQI class average was 70-50 with a range of indicators, while the downstream station (station Sorkhrood) of these indicators in the months except January, June and July reduced to below 50 and as a region with poor water quality (pollution) were identified. Conclusion: Haraz river water at 6 stations (output from Lar dam until Karesang station) based on NSFWQI water quality index evaluated. The range of average quality index was 70-50, while in the downstream stations (station Sorkhrood), the value of these indicators, reduced to below 50, except for the months January, June and July. The station Sorkhrood was identified as an area with poor water quality (pollution). Water quality zoning Haraz River 2012 8 01 64 71 http://jmums.mazums.ac.ir/article-1-1304-en.pdf
73-1320 2024-03-28 10.1002
Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Evaluation of Tooth Staining Using Polyvinylpyrrolidone (PVP) in Combination with Chlorhexidine: in Vivo and in Vitro Study Hojatolla Yoosefi Manesh hojjatyoosefi@yahoo.com Parviz Tork Zaban Davood Habibi Maryam Robati Background and purpose: Chlorhexidine (CHX) is still considered the gold standard anti-plaque agent. The main disadvantage of chlorhexidine is its taste, and staining. Improvements of these disadvantages are time consume. This study was to determine if polyvinylpyrrolidone (PVP) could be added to chlorhexidine rinses to maintain efficacy and reduce staining. Materials and methods: This study divided to in vivo and in vitro.The in vivo was randomized, double blind study, and 40 patients with moderate to severe inflammation enrolled to study. The patients undergone dental polishing before the study. In case study and control used e Chlorhexidine + polyvinylpyrrolidone Chlorhexidine mouth wash for 2 weeks respectively. Plaque index (PI) and gingival index (GI), bleeding index (BI), and stain index were assessed before and after the intervention. The glass block and spectrophotometry was used to examine the staining intensity of each mouthwash in In vitro study. The data in SPSS and statistical methods were analyzed by Wilcoxon Signed Ranks Test. Results: PI, GI, BI, stain index difference between base line of Chlorhexidine + polyvinyl pyrrolidone and Chlorhexidine mouthwash group was not significant, But the amount of interference between the two groups was significant difference (P=0.006, 0.007, 0.042 respectively). Final severity of body and gingiva between base line of Chlorhexidine + polyvinylpyrrolidone and Chlorhexidine mouthwash group was significant (P<0.05). Final extent of body and gingiva between base line of two groups was significant (P<0.05). Conclusion: 0.2% concentration of Chlorhexidine and 5% PVP concentration in clinical practice to decrease side effect of Chlorhexidine but maintain Chlorhexidine effect polyvinyl pyrrolidone chlorhexidine stain mouth rinses in vitro 2012 8 01 74 81 http://jmums.mazums.ac.ir/article-1-1320-en.pdf
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Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 The Correlation of Nasal Mucosal and Systemic Eosinophilia with Chronic Rhinosinusitis Seyyed Abdollah Madani Seyyed Abbas Hashemi abbas.hashemi30@gmail.com Esmaiel Gebraili Background and purpose: Chronic rhinosinusitis is a worldwide health concern with almost unknown etiology. In the current investigation, we explored the relation of nasal mucosal and systemic eosinophilia with chronic inflammation to elucidate the role of eosinophils in chronic rhinosinusitis. Materials and methods: The study population included 50 patients with chronic rhinosinusitis. Samples were collected from all patients’ nasal discharge and peripheral venous blood. In the opinion of investigators, exclusion criteria included the conditions that could influence the immunoglobulins levels such as malignancy, renal dysfunction, vascular diseases, malnutrition, and chemotherapy or radiation therapy. Study was conducted in otorhinolaryngology, head and neck surgery department, Mazandaran University of medical sciences, Sari, Iran from September 2011 to December 2011. Data was analyzed using Cross-Tab and Mann-Whitney tests. Results: The research participants involved 29 (58%) male and 21 (42%) female subjects aged from 5 to 70 years with mean age of 30.6. Nasal mucosal eosinophilia was observed in 42% of the patients (21 participants) and systemic eosinophilia was identified in 15 subjects (30%). 42.3% of patients with nasal mucosal eosinophilia and 46.6% of subjects with systemic eosinophilia revealed pan sinusitis in computed tomography scan. There was no significant correlation between blood and mucosal eosinophilia (p= 0.29). Post nasal discharge (90%), nasal congestion (52%) and headache (50%) were the commonest clinical symptoms. Nasal septal deviation was reported in 14 patients (28%). Conclusion: In the present study, we concluded patients with nasal mucosal and systemic eosinophilia revealed higher severity of symptoms. Such patients require more clinical care and diagnostic evaluation. Chronic rhinosinusitis eosinophil nasal mucosal eosinophilia systemic eosinophilia 2012 8 01 87 83 http://jmums.mazums.ac.ir/article-1-1318-en.pdf
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Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Growth Plate Reappearance after Closure in Ankle Radiography for Trauma Ahmad Shahab Kosarian Masoud Shayesteh Azar mshayestehazar@yahoo.com Seyed Mohammad Mehdi Daneshpoor Bone growth plates or physis are present at the end of long bones and are responsible for longitudinal growth. These plates consist of 4 layers and are lucent in radiography as a line perpendicular to the longitudinal axis, Because of cartilage layer x-ray absorption is less than calcified bone. Gradually increases with age and bone maturity these line will be narrower and as longitudinal bone growth stops, the line disappears. This phenomenon occurs at different ages in different bones of the skeleton but with complete maturity at the age of 19, all growth plates are closed and sclerosed. Re-appearing after closing is uncommon. We introduce two young patients in this study due to trauma have been treated for an ankle cast and the growth plates of tibia and fibula in their control X-ray was re-appeared. Subchondrel Bone Resorbtion is a known phenomenon that will occur after 6 to 8 weeks immobility in any bone. The lucent line caused by imbalance in osteoblast and osteoclast activity and bone absorption. Re-appearing of growth plates can be caused by reversed ossification and bone absorption. Growth plate subchondrel bone resorbtion hawkins sign ankle trauma 2012 8 01 89 93 http://jmums.mazums.ac.ir/article-1-1317-en.pdf
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Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 A Case Report of External Ophthalmomyiasis Abbas Soleymani E-mail: abbassoleymani@yahoo.co.uk Elham Tayebi Sajedeh Omidbakhsh Ophthalmomyiasis is caused by presence of fly larvae Oestrus Ovis which has low incidence rate in the world, but most cases have been reported from developing countries. Recently the prevalence of ophthalmomyiasis has decreased in Iran. In spring 2011, a 40-year old rural woman with a good level of hygiene referred to Ophthalmology department of Rouhani Hospital in Babol. She had no history of eye diseases. After physical examination external ophthalmomyiasis was diagnosed. Seven larvae were found that were removed from cornea and cul-de-sac. Topical antibiotic and corticosteroid were prescribed for daily use. After two days the eye was asymptomatic. Myiasis external ophthalmomyiasis Oestrus ovis 2012 8 01 95 98 http://jmums.mazums.ac.ir/article-1-1325-en.pdf
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Journal of Mazandaran University of Medical Sciences J Mazandaran Univ Med Sci 1735-9260 1735-9279 2012 22 92 Phaeohyphomycosis due to Dematiaceous Fungi A Review of the Literature Mohammad Hosein Afsarian Tahereh Shokohi Mehdi Arzanlou Mehdi Taheri Sarvtin Hamid Badali E-mail:badalii@yahoo.com Melanized fungi are frequently considered as ubiquitous saprobes commonly found on decomposing plant debris, dead plant material, rotten wood, or soil. Over 70 genera and 150 species of dematiaceous fungi have been implicated in human and animal diseases. The clinical syndromes caused by latter fungi are differentiated based on histologic criteria into phaeohyphomycetoma, chromoblastomycosis, and phaeohyphomycosis. Phaeohyphomycosis is a term generally reserved for the remainder of clinical disorder due to black yeast like fungi and relatives. The most important clinical melanized fungi are in the order of Chaetothyriales, e.g. Cladophialophora spp, Exophiala spp, and Rhinocladiella spp. Standard conventional diagnostic procedures are direct microscopy, histopathological staining to document tissue invasion, radiographic and computerized tomography (CT) findings. Recently, assays have focused on non-culture based methods, especially nucleic acid-based methods, such as PCR assays. Most of the invasive infections due to dematiaceous fungi are treated by triazole antifungals, e.g. voriconazole, itraconazole and posaconazole which demonstrated the highest in vitro activity against dematiaceous fungi. Phaeohyphomycosis melanized fungi black yeast antifungal therapy 2012 8 01 100 126 http://jmums.mazums.ac.ir/article-1-1326-en.pdf