Volume 28, Issue 162 (7-2018)                   J Mazandaran Univ Med Sci 2018, 28(162): 37-46 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Imani Z, Saeedi M, Akbari J, Morteza Semnani K, Imani Z. Investigating the Effect of Mixed Surfactants with Different HLBs on the Properties of Solid Lipid Nanoparticle of Spironolactone. J Mazandaran Univ Med Sci 2018; 28 (162) :37-46
URL: http://jmums.mazums.ac.ir/article-1-11543-en.html
Abstract:   (3585 Views)
Background and purpose: This study investigated the effect of different HLBs on these nanoparticles using spironolactone solid lipid nanoparticles.
Materials and methods: The spironolactone loaded SLN was prepared by emulsion/solvent evaporation technique followed by ultrasonication. In this study, Palmitic acid was used as carrier. Different weight ratio of drug, carrier, Span60 and Tween80 were selected. Different formulations were prepared with different HLBs. Nanoparticle properties like particle size, polydispersity index, zeta potential and entrapment efficiency were investigated. Optimum formulation was chosen for evaluation of drug release and other properties of nanoparticles by DSC and FT-IR spectroscopy.
Results: Increasing lipid concentration resulted in consequent increase entrapment efficiency and the size. Also, the F1-F9 formulations showed that Zeta potential was in an acceptable range, and only reduce in HLB in F4 was accompanied with decreasing Zeta potential. Spironolactone was found to have a higher drug release rate in the SLN form. Information from the FT-IR spectroscopy and the DSC thermogram indicated effective entrapment of drug in the carrier.
Conclusion: spironolactone-SLNs provide a controlled and increased drug release rates. Spironolacton-SLN would provide high drug levels at the site of action, therefore, this product could be useful in topical drug delivery.
Full-Text [PDF 674 kb]   (1507 Downloads)    
Type of Study: Research(Original) | Subject: Pharmacy

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Mazandaran University of Medical Sciences

Designed & Developed by : Yektaweb