Volume 31, Issue 196 (5-2021)
J Mazandaran Univ Med Sci 2021, 31(196): 11-22 |
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Parsa H, Mehri Alvar Y, Erfani Aadab F. Effects of Eight Weeks of High Intensity Interval Training Program on Gene Expression Factors Involved in Cholesterol Reverse Transport in Liver Tissue of Ischemic Rat. J Mazandaran Univ Med Sci 2021; 31 (196) :11-22
URL: http://jmums.mazums.ac.ir/article-1-16190-en.html
URL: http://jmums.mazums.ac.ir/article-1-16190-en.html
Abstract: (1999 Views)
Background and purpose: The present study aimed at exploring the effects of eight-week high intensity interval training (HIIT) program on gene expression factors involved in cholesterol reverse transport in liver tissue of ischemic rats.
Materials and methods: In this study, 28 Wistar Rats (250 ±20 g) were randomly divided into four groups: Ischemia (n=8), Placebo (n=8), Training (n=8), and Ischemia plus Training (n=8). Myocardial infarction was induced by ligation of left anterior descending coronary artery (LAD) for 30 minutes. High intensity interval training program (4 min of running at 85-90% VO2max and 2 min active recovery at 50-60% VO2max) was performed using treadmill for 8 weeks (three times a week /40 minutes).
Results: The expression levels of ABCG1 receptor gene and Apolipoprotein A1 significantly increased in high intensity interval training group compared to Ischemia group (P=0.008) and placebo group (P= 0.037). Also, the expression of Apolipoprotein 2 receptor gene showed significant increase in HIIT+ Ischemia group compared to Ischemia group (P=0.041) and placebo group (P=0.04). In addition, the expression of SR-BR receptor gene was found to increase in HIIT+ Ischemia group compared to the placebo group (P=0.028).
Conclusion: High intensity interval training in ischemic rats increases the key factors involved in reverse cholesterol transfer process and ultimately leads to an increase in HDL, which has a positive effect on prevention of atherosclerosis and ischemia.
Materials and methods: In this study, 28 Wistar Rats (250 ±20 g) were randomly divided into four groups: Ischemia (n=8), Placebo (n=8), Training (n=8), and Ischemia plus Training (n=8). Myocardial infarction was induced by ligation of left anterior descending coronary artery (LAD) for 30 minutes. High intensity interval training program (4 min of running at 85-90% VO2max and 2 min active recovery at 50-60% VO2max) was performed using treadmill for 8 weeks (three times a week /40 minutes).
Results: The expression levels of ABCG1 receptor gene and Apolipoprotein A1 significantly increased in high intensity interval training group compared to Ischemia group (P=0.008) and placebo group (P= 0.037). Also, the expression of Apolipoprotein 2 receptor gene showed significant increase in HIIT+ Ischemia group compared to Ischemia group (P=0.041) and placebo group (P=0.04). In addition, the expression of SR-BR receptor gene was found to increase in HIIT+ Ischemia group compared to the placebo group (P=0.028).
Conclusion: High intensity interval training in ischemic rats increases the key factors involved in reverse cholesterol transfer process and ultimately leads to an increase in HDL, which has a positive effect on prevention of atherosclerosis and ischemia.
Keywords: myocardial ischemia, cholesterol reverse transport, high intensity interval training, apolipoprotein
Type of Study: Research(Original) |
Subject:
Sport Physiology
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