Volume 34, Issue 242 (2-2025)                   J Mazandaran Univ Med Sci 2025, 34(242): 158-165 | Back to browse issues page

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Ghazanfari M, Asadi Shahi Sarae S, Yaalimadad S, Nikoueian Shirvan B, Ghanbari S, Mohammad taghi fam H et al . Policy Brief on Managing Nosocomial Aspergillosis and Azole Resistance in Aspergillus Species in the Healthcare System of Iran. J Mazandaran Univ Med Sci 2025; 34 (242) :158-165
URL: http://jmums.mazums.ac.ir/article-1-21543-en.html
Policy Brief on Managing Nosocomial Aspergillosis and Azole Resistance in Aspergillus Species in the Healthcare System of Iran
Mona Ghazanfari , Sabrieh Asadi Shahi Sarae , Sanaz Yaalimadad , Bahador Nikoueian Shirvan , Somayeh Ghanbari , Hossein Mohammad taghi fam , Mohammad Taghi Hedayati
Abstract:   (447 Views)
Invasive aspergillosis is known as one of the most dangerous fungal diseases, especially in immunocompromised individuals or patients with long-term hospitalization in intensive care units. This disease imposes a significant burden on the Iranian health system with its high mortality rate and high costs due to hospitalization and treatment. On the other hand, the increasing resistance of Aspergillus species, especially Aspergillus fumigatus, to azole drugs is a serious challenge. The country's lack of an effective strategy and program to monitor and treat this disease is a major obstacle to its control. Researchers from the Invasive Fungal Research Center affiliated with Mazandaran University of Medical Sciences, by presenting this policy brief report, emphasize the need for immediate action and attention to a multifaceted approach of clinical vigilance, ongoing research, and management of environmental factors, and propose operational solutions including the establishment of continuous clinical and environmental monitoring systems, the development of rapid diagnostic tests, research and development of new drugs, specialized training of medical staff, the development of aspergillosis infection control protocols, and monitoring the use of azole fungicides in agriculture. The development of a comprehensive national program, cooperation between policymakers and health managers, researchers and medical mycologists, and other health and medical specialists, along with interdisciplinary measures, will play an important role in managing this crisis.

 
Keywords: invasive aspergillosis, azole resistance, Aspergillus fumigatus, infection control, policy brief
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Subject: Policy and Management
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