Volume 29, Issue 172 (5-2019)
J Mazandaran Univ Med Sci 2019, 29(172): 121-126 |
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Fathi-Moghadam H, Farbod Y, Ghadiri A A, Fatemi R. Effects of Crocin on Oxidative Stress Indices in Rat Brain Demylated with Ethidium Bromide
. J Mazandaran Univ Med Sci 2019; 29 (172) :121-126
URL: http://jmums.mazums.ac.ir/article-1-12442-en.html
URL: http://jmums.mazums.ac.ir/article-1-12442-en.html
Abstract: (2424 Views)
Background and purpose: The purpose of this study was to investigate the effects of crocin (Cr) on brain oxidative stress indices in animal model demyelinated with intracerebroventricular ethidium bromide (EB).
Materials and methods: In an interventional study, female Wistar rats were randomly divided into 7 groups. Crocin administration was done 1 day after EB injection for 21 days. The values for Glutathione peroxidase (GPx), Superoxide dismutase (SOD), and Malondialdehyde (MDA) were measured before and after receiving Cr and analyzed using Paired t test and ANOVA.
Results: The levels of GPx, SOD, and MDA significantly reduced in the group that received Cr100 mg/kg (P<0.05). The effects of crocin were dose-dependent and other doses did not demonstrate significant effects on oxidative stress indices (P< 0.05).
Conclusion: The antioxidant effects of Crocin were dose-dependent, and it could be used as a strong antioxidant in management of patients with multiple sclerosis.
Materials and methods: In an interventional study, female Wistar rats were randomly divided into 7 groups. Crocin administration was done 1 day after EB injection for 21 days. The values for Glutathione peroxidase (GPx), Superoxide dismutase (SOD), and Malondialdehyde (MDA) were measured before and after receiving Cr and analyzed using Paired t test and ANOVA.
Results: The levels of GPx, SOD, and MDA significantly reduced in the group that received Cr100 mg/kg (P<0.05). The effects of crocin were dose-dependent and other doses did not demonstrate significant effects on oxidative stress indices (P< 0.05).
Conclusion: The antioxidant effects of Crocin were dose-dependent, and it could be used as a strong antioxidant in management of patients with multiple sclerosis.
Type of Study: Brief Report |
Subject:
Pharmacognosy
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