Volume 31, Issue 197 (5-2021)
J Mazandaran Univ Med Sci 2021, 31(197): 1-11 |
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Masodzade G, Barari A, Abbasi daloii A, Farzanegi P. Comparing the Effect of High and Moderate Intensity Exercise Trainings and Resveratrol Supplementation on FGF-21 and Cytokeratin-18 in Rats with Nonalcoholic Fatty Liver Disease. J Mazandaran Univ Med Sci 2021; 31 (197) :1-11
URL: http://jmums.mazums.ac.ir/article-1-14243-en.html
URL: http://jmums.mazums.ac.ir/article-1-14243-en.html
Abstract: (1593 Views)
Background and purpose: There is little evidence about the effect of exercise trainings with different intensities and resveratrol on Nonalcoholic Fatty Liver Disease (NAFLD) indexes. This investigation aimed at studying the effect of 8 weeks of high and moderate intensity exercise training and resveratrol supplementation on alterations of FGF-21 and Cytokeratin-18 levels in NAFLD rats.
Materials and methods: In this experimental study, 48 adult male rats (210±10 gr) were randomly divided into six groups, including a healthy control group, a patient group, rats that received saline, some to do high and moderate intensity exercise trainings, and animals that received resveratrol (10 mg/kg/day). High fat emulsion was used to induce NAFLD. Exercise trainings were performed at 8 weeks, five times a week for 45 minutes. We measured serum levels of FGF-21 and Cytokeratin-18 by ELIZA and FGF21 mRNA by PCR real time method. Data were analyzed by one-way analysis of variance and Tukey’s post-hoc test.
Results: The serum levels of FGF21 mRNA, FGF-21, and Cytokeratin-18 showed significant decrease in resveratrol group, and high and moderate intensity exercise groups compared to the patient group (P≤0.001), but were not significantly different among these three groups (P≤0.001).
Conclusion: The resveratrol supplementation, and high and moderate intensity exercise trainings could decrease FGF-21 and Cytokeratin-18serum levels in NAFALD rats.
Materials and methods: In this experimental study, 48 adult male rats (210±10 gr) were randomly divided into six groups, including a healthy control group, a patient group, rats that received saline, some to do high and moderate intensity exercise trainings, and animals that received resveratrol (10 mg/kg/day). High fat emulsion was used to induce NAFLD. Exercise trainings were performed at 8 weeks, five times a week for 45 minutes. We measured serum levels of FGF-21 and Cytokeratin-18 by ELIZA and FGF21 mRNA by PCR real time method. Data were analyzed by one-way analysis of variance and Tukey’s post-hoc test.
Results: The serum levels of FGF21 mRNA, FGF-21, and Cytokeratin-18 showed significant decrease in resveratrol group, and high and moderate intensity exercise groups compared to the patient group (P≤0.001), but were not significantly different among these three groups (P≤0.001).
Conclusion: The resveratrol supplementation, and high and moderate intensity exercise trainings could decrease FGF-21 and Cytokeratin-18serum levels in NAFALD rats.
Keywords: aerobic exercise, resveratrol, fibroblast growth factor 21, Cytokeratin-18, nonalcoholic fatty liver
Type of Study: Research(Original) |
Subject:
Sport Physiology
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